628293-21-0Relevant articles and documents
A New Generation of N-Aryl-N′-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics
Mounetou, Emmanuelle,Legault, Jean,Lacroix, Jacques,Gaudreault, René C.
, p. 5055 - 5063 (2007/10/03)
New N-aryl-N′-2-chloroethylureas (CEUs) with enhanced cytotoxicity were developed as antimitotic agents potentially useful in cancer chemotherapy. Highly potent CEUs were obtained by introduction of a branched alkylating chain, the N′-(1-methyl-2-chloro)e