6283-10-9

Basic information

• Product Name: 2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxane
• CAS NO: 6283-10-9
• Molecular Formula: C₁₂H₁₅ClO₂
• Molecular Weight: 226.6993
• Mol File: 6283-10-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 299.2°C at 760 mmHg
• Flash Point: 102.8°C
• Density: 1.116g/cm³
• Vapor Pressure: 0.00215mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxane(6283-10-9)
• EPA Substance Registry System: 2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxane(6283-10-9)

Safety Data

• Hazardous Substances Data: 6283-10-9(Hazardous Substances Data)

Usage

Structure

A dioxane derivative with a chlorophenyl group and two methyl groups attached to the dioxane ring.

Usage

Commonly used as an intermediate in the pharmaceutical and chemical industries for the synthesis of various drugs and organic compounds.

Applications

Serves as a building block for the production of agrochemicals, fragrances, and pharmaceuticals.

Research and development

Utilized in the creation of new chemical compounds.

Precautions

Potential health hazards and environmental effects if not properly managed.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 103-82-2 phenylacetic acid 
• 599-67-7 1,1-diphenylethanol 
• 60-12-8 2-phenylethanol 
• 555-16-8 4-nitrobenzaldehdye 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 38216-97-6 3-(p-Chlor-benzyloxy)-2,2-dimethyl-propanol-⁽¹⁾ 
• 1243701-34-9 C₁₇H₂₃ClO₃ 
• 13086-93-6 (acetyloxy)(4-chlorophenyl)methyl acetate 
• 106456-92-2 p-formylbenzonitrile neopentyl glycol acetal 

Relevant articles and documents

Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation

Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.

Bismuth compounds in organic synthesis: Synthesis of dioxanes, dioxepines, and dioxolanes catalyzed by bismuth(III) triflate

A simple method for the synthesis of 1,3-dioxolanes from carbonyl compounds has been developed using 1,2-bis(trimethylsilyloxy)ethane in the presence of bismuth(III) triflate as a catalyst. The bismuth(III) triflate catalyzed synthesis of a range of dioxanes and dioxepines has also been developed. In these latter cases, the carbonyl compound is treated with a diol, and triethyl orthoformate is used as a water scavenger. All these methods avoid the use of a Dean-Stark trap. Georg Thieme Verlag Stuttgart.

Sulfated zirconia as an efficient catalyst for tetrahydro pyranylation and acetalization

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