628322-77-0

Basic information

• Product Name: 2-Pyridinamine, N-(diphenylmethylene)-3-fluoro-
• CAS NO: 628322-77-0
• Molecular Formula: C18H13FN2
• Molecular Weight: 276.313
• Mol File: 628322-77-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyridinamine, N-(diphenylmethylene)-3-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, N-(diphenylmethylene)-3-fluoro-(628322-77-0)
• EPA Substance Registry System: 2-Pyridinamine, N-(diphenylmethylene)-3-fluoro-(628322-77-0)

Safety Data

• Hazardous Substances Data: 628322-77-0(Hazardous Substances Data)

Upstream product

• 1013-88-3 Benzophenone imine 
• 17282-04-1 2-chloro-3-fluoropyridine 

Downstream Products

• 139022-26-7 8-fluoroimidazo[1,2-a]pyridine 

Relevant articles and documents

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor

8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques. Furthermore, a novel synthesis of a 3,7-disubstituted-8- fluoroimidazopyridine 3 has been developed and the utility of the physicochemical mimicry has been demonstrated in an in vitro system. Here, the 8-fluoroimidazopyridine ring contained in ligand 3 acts as a bioisosteric replacement for imidazopyrimidine in the GABAA receptor modulator 2.

8-FLUORIMIDAZO`1,2-A!PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoroimidazo[1,2-a]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.