62855-72-5

Basic information

• Product Name: ethyl 2-(3,4-dichlorophenoxy)acetate
• Synonyms: ethyl 2-(3,4-dichlorophenoxy)acetate;Ethyl 3,4-dichlorophenyloxy acetate;Acetic acid, (3,4-dichlorophenoxy)-, ethyl ester;(3,4-DICHLOROPHENOXY)-ACETIC ACID ETHYL ESTER
• CAS NO: 62855-72-5
• Molecular Formula: C₁₀H₁₀Cl₂O₃
• Molecular Weight: 249.0906
• Mol File: 62855-72-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 41-43 °C
• Boiling Point: 160-161 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.308±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl 2-(3,4-dichlorophenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3,4-dichlorophenoxy)acetate(62855-72-5)
• EPA Substance Registry System: ethyl 2-(3,4-dichlorophenoxy)acetate(62855-72-5)

Safety Data

• Hazardous Substances Data: 62855-72-5(Hazardous Substances Data)

Upstream product

• 588-22-7 (3,4-dichlorophenoxy)acetic acid 
• 95-77-2 3,4-dichlorophenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 13359-31-4 2-(3,4-dichlorophenoxy)acetohydroxamic acid 
• 13359-31-4 (3,4-Dichlor-phenoxy)-acetohydroxamsaeure 
• 1489287-86-6 1-(3,4-dichlorophenoxyacetyl)-4-(4-phenylbenzyl)-thiosemicarbazide 
• 32022-41-6 3,4-dichlorophenoxyacetic acid hydrazide 
• 588-22-7 (3,4-dichlorophenoxy)acetic acid 

Relevant articles and documents

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

CHEMCICAL COMPOUNDS

The invention is directed to substituted pyrrolidine derivatives. Specifically, the invention is directed to compounds according to Formula III: wherein A, B, L1, L2, L3, R1, R2, R3, R4, R5, R6, R9, R10, R30, Y1, Y2, z2, z4, z5, and z6 are as defined herein, and salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and acute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group

Osteoarthritis is a disabling disease characterized by the articular cartilage breakdown. Aggrecanases are potential therapeutic targets for the treatment of this pathology. At the starting point of this project, an acylthiosemicarbazide was discovered to inhibit aggrecanase-2. The acylthiosemicarbazide Zn binding group is also a convenient linker for library synthesis. A focused library of 920 analogs was thus prepared and screened to establish structure-activity relationships. The modification of the acylthiosemicarbazide was also explored. This strategy combining library design and discrete compounds synthesis yielded inhibitor 35, that is highly selective for aggrecanases over a panel of metalloproteases and inhibits the degradation of native fully glycosylated aggrecan. A docking study generated binding conformations explaining the structure-activity relationships.