6286-49-3

Basic information

• Product Name: 2-(3,4-dimethoxyphenyl)butanedinitrile
• CAS NO: 6286-49-3
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.2359
• Mol File: 6286-49-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 410.3°C at 760 mmHg
• Flash Point: 170.7°C
• Density: 1.133g/cm³
• Vapor Pressure: 6.1E-07mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 2-(3,4-dimethoxyphenyl)butanedinitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethoxyphenyl)butanedinitrile(6286-49-3)
• EPA Substance Registry System: 2-(3,4-dimethoxyphenyl)butanedinitrile(6286-49-3)

Safety Data

• Hazardous Substances Data: 6286-49-3(Hazardous Substances Data)

Usage

Structure

Contains a benzene ring with two methoxy groups (-OCH3) attached to the 3 and 4 positions, and two nitrile groups (-C≡N) attached to a butane chain.

Type of compound

A chemical compound that is a nitrile derivative of 3,4-dimethoxybenzophenone.

Uses

Commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Reactivity

Unique reactivity and properties due to the presence of two nitrile groups and two methoxy groups on the benzene ring.

Applications

Mainly used in organic synthesis and found in various research and development applications.

Handling precautions

Potential hazards and reactivity should be considered, and the compound should be handled with care.

Upstream product

• 24393-47-3 ethyl (E)-2-cyano-3-(3,4-dimethoxyphenyl)-2-propenoate 
• 143-33-9 sodium cyanide 
• 2286-55-7 ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 773837-37-9 sodium cyanide 

Downstream Products

• 153718-52-6 4-acetamido-3-(3,4-dimethoxyphenyl)butyronitrile 
• 38175-31-4 (+/-)-3-(3,4-dimethoxyphenyl)pyrrolidine 
• 94357-76-3 3-(3,4-dimethoxyphenyl)pyrrolidine-2,5-dione 
• 94357-77-4 2-(3,4-dimethoxyphenyl)-N-(n-propyl)succinimide 
• 94357-78-5 3-(3,4-dimethoxyphenyl)-1-n-propylpyrrolidine 
• 153718-53-7 1-acetamido-4-amino-2-(3,4-dimethoxyphenyl)butane 

Relevant articles and documents

Ring Opening of Donor-Acceptor Cyclopropanes with Cyanide Ion and Its Surrogates

A straightforward method for ring opening of donor-acceptor cyclopropanes with trimethylsilyl cyanide as a surrogate of cyanide ion in the presence of B(C6F5)3 or trifluoromethanesulfonic acid as a catalyst has been developed. The methodology provides a short route to γ-cyanoesters that can be useful synthetic intermediates for the synthesis of diverse bioactive molecules such as glutaric and δ-aminovaleric acid derivatives, 3-arylpiperidines, or other substituted phenethylamines. Oppositely, the attempts to synthesize these γ-cyanoesters by direct reaction of cyclopropanes with sodium cyanide under typical SN2 conditions led to the formation of 2-arylsuccinonitriles.

Synthesis and dopaminergic activity of 3-(3,4-dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide

3-(3,4-Dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide was synthesized by a six-step reaction sequence and was evaluated, and compared with apomarphine, for central dopaminergic agonist activity. The compound produced behavioral and biochemical change