628725-99-5

Basic information

• Product Name: 2-BROMO-6-(TRIFLUOROMETHOXY)BENZOTHIAZOLE
• Synonyms: 2-BROMO-6-(TRIFLUOROMETHOXY)BENZOTHIAZOLE;2-Bromo-6-(trifluoromethoxy)benzo[d]thiazole
• CAS NO: 628725-99-5
• Molecular Formula: C8H3BrF3NOS
• Molecular Weight: 298.08
• Mol File: 628725-99-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 289.383 °C at 760 mmHg
• Flash Point: 128.815 °C
• Appearance: /
• Density: 1.831 g/cm³
• PKA: -1.20±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-6-(TRIFLUOROMETHOXY)BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-(TRIFLUOROMETHOXY)BENZOTHIAZOLE(628725-99-5)
• EPA Substance Registry System: 2-BROMO-6-(TRIFLUOROMETHOXY)BENZOTHIAZOLE(628725-99-5)

Safety Data

• Hazardous Substances Data: 628725-99-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-(trifluoromethoxy)benzothiazole is a specialized chemical compound that belongs to the organobromine and organofluorine classes of substances. The presence of bromine and the trifluoromethoxy group suggests that this compound might have important reactivity traits. The benzothiazole core is a key structural component widely found in various drugs and compounds with a range of biological activities, implying that this compound might have potential significance in pharmaceutical, medicinal chemistry, or biochemical research applications. However, detailed properties such as its physical characteristics, toxicity profile, reactivity, and possible uses have not been widely studied or reported in literature, indicating that it's likely a subject of niche or ongoing research.

Upstream product

• 1744-22-5 Riluzole 

Relevant articles and documents

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

DERIVATIVES OF HETEROARYLSULFONAMIDES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPY

The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents ?C(=O)-, or B represents CH when n=0 and D represents ?CH2O? or when n=1 and D represents ?O?, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts.