62921-74-8 Usage
Description
2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate, also known as m-PEG4-Tos, is a PEG linker containing a tosyl group. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions, while the hydrophilic PEG spacer enhances solubility in aqueous media. This unique structure makes m-PEG4-Tos a versatile compound with potential applications in various fields.
Uses
Used in Organic Synthesis:
m-PEG4-Tos is used as a protecting group in organic synthesis for alcohols, particularly in the synthesis of complex organic molecules. The tosyl group's reactivity as a leaving group allows for selective protection and deprotection of alcohols during multi-step reactions, facilitating the synthesis of target molecules.
Used in Bioconjugation:
In the field of bioconjugation, m-PEG4-Tos is employed as a coupling agent to attach biomolecules, such as proteins or nucleic acids, to other molecules or surfaces. The tosyl group's reactivity enables the formation of stable covalent bonds with nucleophilic functional groups present in biomolecules, allowing for the creation of bioconjugates with controlled structure and function.
Used in Drug Delivery Systems:
m-PEG4-Tos is utilized as a component in the design of drug delivery systems, particularly for the development of targeted drug carriers. The hydrophilic PEG spacer improves the solubility and stability of drug carriers in aqueous environments, while the tosyl group can be used for selective conjugation of therapeutic agents, enabling the development of targeted drug delivery systems with enhanced efficacy and reduced side effects.
Used in Material Science:
In material science, m-PEG4-Tos is used as a building block for the synthesis of novel polymers and materials with tailored properties. The combination of the hydrophilic PEG spacer and the reactive tosyl group allows for the creation of materials with specific interactions, such as self-assembly, stimuli-responsive behavior, or controlled release of encapsulated molecules.
Used in Analytical Chemistry:
m-PEG4-Tos is employed as a derivatization agent in analytical chemistry for the enhancement of detection and analysis of various analytes. The tosyl group's reactivity enables the formation of stable derivatives with improved chromatographic or spectroscopic properties, facilitating the detection and quantification of target analytes in complex samples.
Check Digit Verification of cas no
The CAS Registry Mumber 62921-74-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,9,2 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 62921-74:
(7*6)+(6*2)+(5*9)+(4*2)+(3*1)+(2*7)+(1*4)=128
128 % 10 = 8
So 62921-74-8 is a valid CAS Registry Number.
62921-74-8Relevant articles and documents
FLUORINATED AMINE OXIDE SURFACTANTS
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, (2022/02/27)
Compositions including one or more fluorochemical surfactants of the formula: (I) where Rf is a perfluoroalkyl group, each of R1, R2 and R3 are C1-C20 alkyl, alkoxy, or aryl; and R4 is alkylene, arylene of a combination thereof. R4 is preferably an alkylene of 1-20 carbons that may be cyclic or acyclic, may optionally contain catenated or terminal heteroatoms selected from the group consisting of N, O, and S. Most preferably R4 is an alkylene of 2-10 carbon atoms. Described are anionic N-substituted fluorinated amine oxide surfactants, and use thereof in cleaning and in acid etch solutions. The cleaning and etch solutions are used with a wide variety of substrates, for example, in the cleaning and etching of silicon oxide-containing substrates.
Modulating optical and electrochemical properties of perylene dyes by twisting aromatic π-system structures
Wang, Ying,Zhang, Qi,Gong, Junbo,Zhang, Xin
, (2021/03/04)
Three highly fluorescent perylene bisimide dyes were synthesized, where aromatic π-system structures are twisted to different degree by steric hindrance of two or four substitution groups at bay position. Light-emitting colours of these dye solutions can be modulated from green, yellow to red, and their fluorescence quantum yields increase up to approximate 100% with increasing the π-system twisting, which can be considered for new class of wavelength-tunable dye lasers. π-Twisted dyes are more sensitive to microenvironment changes. Thus, they are better fluorescence probe and sensory materials than planar dyes. Electrochemical cyclic voltammetry measurements revealed that these dyes are suitable for n-type optoelectrical devices and materials. These dye solids display near infra-red emission at 600–850 nm. Owing to strong π-π stacking interaction, planar dye solid loses its outstanding optical properties compared to its solution. In contrast, π-twisted dye solids retain their excellent optical properties including narrow emission bands and relatively high fluorescence quantum yields due to the suppression of π-π stacking interaction. Exceptional fluorescence polarization phenomena were observed for these π-twisted dye solids. These optical results revealed that π-twisted perylene bisimide dyes are more excellent optical materials than planar dyes.
NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
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Page/Page column 37-38, (2021/08/13)
Nerve-specific fluorophore formulations of Formula (I) for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.
