6293-09-0

Basic information

• Product Name: 5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE
• Synonyms: 5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE
• CAS NO: 6293-09-0
• Molecular Formula: C5H4N4O2
• Molecular Weight: 152.11
• Mol File: 6293-09-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 896.5°Cat760mmHg
• Flash Point: 496°C
• Appearance: /
• Density: 1.637g/cm³
• Vapor Pressure: 5.51E-08mmHg at 25°C
• Refractive Index: 1.989
• CAS DataBase Reference: 5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE(6293-09-0)
• EPA Substance Registry System: 5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE(6293-09-0)

Safety Data

• Hazardous Substances Data: 6293-09-0(Hazardous Substances Data)

Usage

General Description

5,6-Dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione is a chemical compound with a heterocyclic structure. It is a heterocyclic compound that contains both nitrogen and oxygen atoms in its ring structure. 5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE has potential medicinal properties and has been studied for its potential use as a therapeutic agent. It is also known for its role in the synthesis of other organic compounds. The chemical structure and properties of 5,6-Dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione make it an interesting molecule for further research and potential applications in medicine and chemical synthesis.

InChI:InChI=1/C5H4N4O2/c10-4-2-3(7-1-6-2)5(11)9-8-4/h1-3H,(H,6,7)

Upstream product

• 3304-70-9 dimethyl imidazole-4,5-dicarboxylate 
• 5423-20-1 1H-imidazole-4,5-dicarboxylic acid dihydrazide 
• 1080-79-1 imidazole 4,5-dicarboxylic acid diethyl ester 

Downstream Products

• 28683-00-3 7-chloro-1,5-dihydro-imidazo[4,5-d]pyridazin-4-one 
• 17998-43-5 4,7-dichloro-1H-imidazo[4,5-d]pyridazine 
• 5453-50-9 5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dithione 
• 100114-30-5 7-methylsulfanyl-1,5-dihydro-imidazo[4,5-d]pyridazine-4-thione 
• 1057681-55-6 7-benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-imidazo[4,5-d]pyridazine 

Relevant articles and documents

1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, that act via antagonism of the Smoothened receptor. A variety of analogues were synthesized and their structure-activity relationships determined. This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.