62940-90-3

Basic information

• Product Name: 2-(3-oxo-1,3-diphenylpropyl)malononitrile
• CAS NO: 62940-90-3
• Molecular Weight: 274.322
• Mol File: 62940-90-3.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: 2-(3-oxo-1,3-diphenylpropyl)malononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-oxo-1,3-diphenylpropyl)malononitrile(62940-90-3)
• EPA Substance Registry System: 2-(3-oxo-1,3-diphenylpropyl)malononitrile(62940-90-3)

Safety Data

• Hazardous Substances Data: 62940-90-3(Hazardous Substances Data)

Upstream product

• 614-47-1 1,3-diphenyl-propen-3-one 
• 109-77-3 malononitrile 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 2700-22-3 Benzylidenemalononitrile 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 94-41-7 benzalacetophenone 
• 95-53-4 o-toluidine 
• 94360-09-5 3-benzoyl-1-bromo-2-phenyl-1,1-dicyanopropane 
• 124-41-4 sodium methylate 

Downstream Products

• 58327-74-5 4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 94360-21-1 2-Chloro-2-(3-oxo-1,3-diphenyl-propyl)-malononitrile 
• 5344-60-5 methyl 4-oxo-2,4-diphenylbutanoate 
• 6268-00-4 4-oxo-2,4-diphenylbutanenitrile 
• 1208944-44-8 2-(3-nitrophenyl)-4-oxo-4-phenylbutanenitrile 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 80827-24-3 1,3-Diphenyl-pyrido<1,2-a>benzimidazol-4-carbonitril 

Relevant articles and documents

Kinetic study of Michael addition catalyzed by N-methylimidazole in ionic liquids: Residual N-methylimidazole in ionic liquids as a strong base

Michael addition of malonodinitrile to chalcone was studied in classical organic solvent as well as in some common ionic liquids (ILs). Kinetic studies proved that the reaction proceeded faster in the studied ILs than in molecular solvents. N-methylimidaz

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

Chloramphenicol base chemistry. Part 11: chloramphenicol base-derived thiourea-catalyzed enantioselective Michael addition of malononitrile to α,β-unsaturated ketones

The first chloramphenicol base-derived thiourea-catalyzed enantioselective Michael addition of malononitrile to α,β-unsaturated ketones is reported. The Michael adducts were obtained in good to excellent yields (up to 98% yield) and enantioselectivities (up to 94% ee). This reaction has a broad substrate scope to various α,β-unsaturated ketones. With this in mind, this methodology was successfully applied to the synthesis of a chiral piperidone, an advanced building block for dihydropyridinone P2X7 receptor antagonists.