629604-05-3

Basic information

• Product Name: 9H-Purine-6-methanol, 9-(phenylmethyl)-
• CAS NO: 629604-05-3
• Molecular Formula: C13H12N4O
• Molecular Weight: 240.264
• Mol File: 629604-05-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 9H-Purine-6-methanol, 9-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purine-6-methanol, 9-(phenylmethyl)-(629604-05-3)
• EPA Substance Registry System: 9H-Purine-6-methanol, 9-(phenylmethyl)-(629604-05-3)

Safety Data

• Hazardous Substances Data: 629604-05-3(Hazardous Substances Data)

Upstream product

• 83135-13-1 9-benzyl-6-iodo-9H-purine 
• 1928-76-3 9-benzyl-6-chloro-9H-purine 
• 13398-11-3 iodomethyl acetate 
• 773133-76-9 6-(benzoyloxymethyl)-9-benzylpurine 
• 773133-70-3 9-benzyl-6-(pivaloyloxymethyl)purine 
• 773133-82-7 6-(acetyloxymethyl)-9-benzylpurine 
• 50-00-0 formaldehyd 

Downstream Products

• 865434-77-1 9-benzyl-6-(methanesulfonyloxymethyl)purine 
• 906482-31-3 9-benzyl-6-formylpurine 
• 865434-81-7 9-benzyl-6-(iodomethyl)purine 

Relevant articles and documents

6-Magnesiated Purines: Preparation and Reaction with Aldehydes

(Equation presented) Halogen-metal exchange reaction of 9-benzyl-6-iodopurine with iPrMgCl in toluene at -80°C proceeds almost quantitatively. Such a purine-derived Grignard reagent reacts selectively with aldehydes in toluene, giving the corresponding alcohols in 25-62% yield, while other functional groups such as ketones, esters, and nitriles do not react under these conditions. The reaction can be extended to protected 6-iodopurine ribonucleoside.

Facile and efficient synthesis of 6-(hydroxymethyl)purines

(Chemical Equation Presented) A facile and efficient methodology of the synthesis of 6-(hydroxymethyl)purine derivatives (bases and nucleosides) was developed based on Pd-catalyzed cross-coupling reactions of 6-halopurines with acyloxymethylzinc iodides f