62967-00-4Relevant articles and documents
[(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 1. Effects of nitrogen and aromatic nuclear substitution
Lee,Plattner,Ours,Horrom,Smital,Pernet,Bunnell,El Masry,Dodge
, p. 1579 - 1587 (2007/10/02)
A series of Mannich bases and aminomethyl derivatives of ethyl [2,3-dichloro-4-(4-hydroxybenzoyl)phenoxy]acetate were synthesized and tested for saluretic and diuretic activities. The effects of nitrogen and aromatic nuclear substitution, reorientation of
4-Aroyl-substituted phenoxy acetic acids
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, (2008/06/13)
This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula STR1 wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is --CH2 COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring. These compounds are useful as antihypertensive agents, diuretics and uricosuric agents.