62978-52-3

Basic information

• Product Name: methyl 4-[bis(2-chloroethyl)amino]phenylalaninate
• Synonyms: phenylalanine, 4-[bis(2-chloroethyl)amino]-, methyl ester
• CAS NO: 62978-52-3
• Molecular Formula: C₁₄H₂₀Cl₂N₂O₂*ClH
• Molecular Weight: 319.2268
• Mol File: 62978-52-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 437.6°C at 760 mmHg
• Flash Point: 218.5°C
• Density: 1.244g/cm³
• Vapor Pressure: 7.36E-08mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: methyl 4-[bis(2-chloroethyl)amino]phenylalaninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[bis(2-chloroethyl)amino]phenylalaninate(62978-52-3)
• EPA Substance Registry System: methyl 4-[bis(2-chloroethyl)amino]phenylalaninate(62978-52-3)

Safety Data

• Hazardous Substances Data: 62978-52-3(Hazardous Substances Data)

Usage

General Description

Methyl 4-[bis(2-chloroethyl)amino]phenylalaninate is a chemical compound that is commonly known as sarin, a potent nerve agent and chemical weapon. It is a toxic and highly dangerous organophosphorus compound that acts by inhibiting the enzyme acetylcholinesterase, leading to the accumulation of the neurotransmitter acetylcholine in the nervous system. Exposure to sarin can cause a range of symptoms, including muscle twitching, respiratory distress, and ultimately paralysis and death. It is classified as a weapon of mass destruction and is strictly regulated under international treaties. Its production, stockpiling, and use are prohibited, and efforts are ongoing to eliminate existing stockpiles and prevent its proliferation.

Upstream product

• 67-56-1 methanol 
• 148-82-3 L-PAM 
• 77-76-9 2,2-dimethoxy-propane 
• 1217651-06-3 N-(t-butyloxycarbonyl)-4-[bis(2-hydroxyethyl)amino]-L-phenylalanine methyl ester 

Downstream Products

• 79145-90-7 Ac-Asn-Arg-Val-Tyr-Val-His-Pro-Mel-OMe 
• 265645-66-7 (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-propionic acid methyl ester 
• 265645-65-6 (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester 
• 265645-64-5 (S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(5-bromo-2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester 
• 148-82-3 L-PAM 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF MELPHALAN HYDROCHLORIDE

The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity.

Alkylating Angiotensin II Analogues: Synthesis, Analysis, and Biological Activity of Angiotensin II Analogues Containing the Nitrogen Mustard Melphalan in Position 8

Melphalan derivatives suitable for peptide synthesis, i.e., Boc-Mel and Mel-OBzl*HCl, have been prepared, and the integrity of their nitrogen mustard alkylating groups was examined by NMR, Volhard chlorine analysis, and colorimetric assay with 4-(p-nitrob