6299-09-8

Basic information

• Product Name: 7-methoxy-2-methyl-3,4-dihydro-2H-phenanthren-1-one
• Synonyms: 7-methoxy-2-methyl-3,4-dihydro-2H-phenanthren-1-one
• CAS NO: 6299-09-8
• Molecular Formula: C16H16O2
• Molecular Weight: 0
• Mol File: 6299-09-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 404.9°C at 760 mmHg
• Flash Point: 186.3°C
• Appearance: /
• Density: 1.139g/cm³
• Vapor Pressure: 9.1E-07mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 7-methoxy-2-methyl-3,4-dihydro-2H-phenanthren-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-2-methyl-3,4-dihydro-2H-phenanthren-1-one(6299-09-8)
• EPA Substance Registry System: 7-methoxy-2-methyl-3,4-dihydro-2H-phenanthren-1-one(6299-09-8)

Safety Data

• Hazardous Substances Data: 6299-09-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 3079, 1947 DOI: 10.1021/ja01204a045

InChI:InChI=1/C16H16O2/c1-10-3-6-14-13-8-5-12(18-2)9-11(13)4-7-15(14)16(10)17/h4-5,7-10H,3,6H2,1-2H3

Upstream product

• 7664-93-9 sulfuric acid 
• 28901-20-4 4-(6-methoxy-[1]naphthyl)-2-methyl-butyric acid 
• 7664-39-3 hydrogen fluoride 
• 6636-51-7 methyl 1,2,3,4-tetrahydro-1-hydroxy-7-methoxy-1-methoxycarbonylmethyl-2-methylphenanthrene-2-carboxylate 
• 71-43-2 benzene 
• 31184-49-3 7-methoxy-2,3-dihydrophenanthren-4(1H)-one 
• 74-88-4 methyl iodide 

Downstream Products

• 60774-50-7 7-Methoxy-2-methyl-2-phenylsulfanyl-3,4-dihydro-2H-phenanthren-1-one 

Relevant articles and documents

Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic

The development of new chemical tools with improved properties is essential to chemical and cell biology. Of particular interest is the development of mimics of small molecules with important cellular function that allow the direct observation of their trafficking in a cell. To this end, a novel 15-azasterol has been designed and synthesized as a luminescent cholesterol mimic for the monitoring of cholesterol trafficking. The brightness of this probe, which is ～32-times greater than the widely used dehydroergosterol probe, is combined with resistance to photobleaching in solution and in human fibroblasts and an exceptionally large Stokes-like shift of ～150-200 nm. The photophysical properties of the probe have been studied experimentally and computationally, suggesting an intersystem crossing to the triplet excited state with subsequent phosphorescent decay. Molecular dynamics simulations show a similar binding mode of cholesterol and the azasterol probe to NPC proteins, demonstrating the structural similarity of the probe to cholesterol.