630-60-4 Usage
Description
One of several
cardiac glycosides that have been used clinically as cardiotonic
agents and diuretics. Ouabain is obtained from the seeds of
Strophanthus gratus, Acokanthera ouabaio, and related species.
It was formerly prescribed under the name strophanthuis as the
purified seed extract.
General Description
Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
Reactivity Profile
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
Health Hazard
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
Fire Hazard
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
Biological Activity
Selective Na + , K + -ATPase inhibitor.
Safety Profile
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Check Digit Verification of cas no
The CAS Registry Mumber 630-60-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 630-60:
(5*6)+(4*3)+(3*0)+(2*6)+(1*0)=54
54 % 10 = 4
So 630-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h12,14H,2-11,15-17H2,1H3,(H,19,20)
630-60-4Relevant articles and documents
Total synthesis of ouabagenin and ouabain
Zhang, Hongxing,Sridhar Reddy, Maddi,Phoenix, Serge,Deslongchamps, Pierre
, p. 1272 - 1275 (2008/12/22)
(Chemical Equation Presented) The highly oxygenated steroid ouabagenin (1b) and its glycoside ouabain (1a) were prepared by a strategy based on a polyanionic cyclization. Starting building blocks A and B were combined to give the key intermediate C and transformed into 1b in 27 steps. Finally, ouabagenin (1b) was converted into ouabain (1a) in six steps (see scheme).