63002-70-0Relevant articles and documents
Quinazolinone-schiff's base hybrids as phosphodiesterase 4b inhibitors with dual activity against COPD and lung cancer
Mansour, Mostafa A.,El-Saadi, Mohamed T.,Amin, Noha H.,Canzoneri, Joshua C.,Keeton, Adam B.,Piazza, Gary A.,Abdel-Rahman, Hamdy M.
, p. 4851 - 4866 (2020/12/25)
A series of thirty compounds of quinazolinone-Schiff's base hybrids were rationally designed, synthesized, and evaluated for their in vitro Phosphodiesterase 4B inhibition, anti-lung and anti-colon cancer activities. Compounds 9, 16, 23, 29, 30, 31, 32 an
Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases
Khan, Mahmud Tareq Hassan,Khan, Rasool,Wuxiuer, Yimingjiang,Arfan, Mohammad,Ahmed, Manzoor,Sylte, Ingebrigt
scheme or table, p. 4317 - 4327 (2010/09/12)
A combinatorial series of novel quinazolin-4(3H)-ones were synthesised and their structures were established based on spectroscopic data (IR, NMR, EI-MS, and FAB-MS). The compounds were tested for inhibition of the zinc metalloproteinase thermolysin (TLN) utilizing a chemical array-based approach. Some of the compounds were found to inhibit TLN, with IC50 values ranging from 0.0115 μM (compound 3) to 122,637 μM (compound 29). Compound 3 [3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one] (IC50 = 0.0115 μM) and compound 35 [3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H)-one] (IC50 = 0.2477 μM) were found to be the most potent inhibitors.
A New Synthesis of 2-Aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones
Reddy, Ch. K.,Reddy, P. S. N.,Ratnam, C. V.
, p. 902 - 904 (2007/10/02)
The reaction of 2-aryl-3,1-benzoxazine-4-ones (1) and hydrazine hydrate in refluxing xylene yields 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones in 55-74percent yield.In basic conditions this reaction, however, gives 2-aryl-3-aminoquinazolin-4(3H)-one
