6301-63-9

Basic information

• Product Name: 1,2-diphenylpentan-2-ol
• Synonyms: 1,2-diphenylpentan-2-ol
• CAS NO: 6301-63-9
• Molecular Formula: C₁₇H₂₀O
• Molecular Weight: 240.34
• Mol File: 6301-63-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 352.3°C at 760 mmHg
• Flash Point: 135.7°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 1.44E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1,2-diphenylpentan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-diphenylpentan-2-ol(6301-63-9)
• EPA Substance Registry System: 1,2-diphenylpentan-2-ol(6301-63-9)

Safety Data

• Hazardous Substances Data: 6301-63-9(Hazardous Substances Data)

Usage

Physical state

White, crystalline solid

Odor

Faint

Classification

Secondary alcohol

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of other organic compounds

Use as

a. Chiral ligand for asymmetric syntheses
b. Reagent in organic chemical reactions

Structural features

a. Five-carbon chain
b. Two phenyl groups attached to the second carbon
c. Hydroxyl group attached to the second carbon

Versatility

Wide range of applications in organic chemistry

InChI:InChI=1/C17H20O/c1-2-13-17(18,16-11-7-4-8-12-16)14-15-9-5-3-6-10-15/h3-12,18H,2,13-14H2,1H3

Upstream product

• 495-40-9 propiophenone 
• 6921-34-2 benzylmagnesium chloride 
• 5281-18-5 benzaldehyde, hydrazone 
• 80735-94-0 1-Phenyl-3-buten-1-ol 

Downstream Products

• 110826-49-8 1,2-diphenylpentane 

Relevant articles and documents

Synergistic Relay Reactions To Achieve Redox-Neutral α-Alkylations of Olefinic Alcohols with Ruthenium(II) Catalysis

Herein, we report a ruthenium-catalyzed redox-neutral α-alkylation of unsaturated alcohols based on a synergistic relay process involving olefin isomerization (chain walking) and umpolung hydrazone addition, which takes advantage of the interaction between the two rather inefficient individual reaction steps to enable an efficient overall process. This transformation shows the compatibility of hydrazone-type “carbanions” and active protons in a one-pot reaction, and at the same time achieves the first Grignard-type nucleophilic addition using olefinic alcohols as latent carbonyl groups, providing a higher yield of the corresponding secondary alcohol than the classical hydrazone addition to aldehydes does. A broad scope of unsaturated alcohols and hydrazones, including some complex structures, can be successfully employed in this reaction, which shows the versatility of this approach and its suitability as an alternative, efficient means for the generation of secondary and tertiary alcohols.