630116-10-8

Basic information

• Product Name: 1-Piperazineacetamide, N-(3-methylphenyl)-4-(2-nitrophenyl)-
• CAS NO: 630116-10-8
• Molecular Formula: C19H22N4O3
• Molecular Weight: 354.409
• Mol File: 630116-10-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Piperazineacetamide, N-(3-methylphenyl)-4-(2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineacetamide, N-(3-methylphenyl)-4-(2-nitrophenyl)-(630116-10-8)
• EPA Substance Registry System: 1-Piperazineacetamide, N-(3-methylphenyl)-4-(2-nitrophenyl)-(630116-10-8)

Safety Data

• Hazardous Substances Data: 630116-10-8(Hazardous Substances Data)

Upstream product

• 59084-06-9 1-(2-nitrophenyl)piperazine 
• 108-44-1 1-amino-3-methylbenzene 
• 5439-17-8 2-bromo-N-(3-methylphenyl)acetamide 

Relevant articles and documents

Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3- methylphenyl)acetamides: Selective dopamine D4 receptor agonists

Diaryl piperazine acetamides were identified as potent and selective dopamine D4 receptor agonists. Our strategy is based on an amide bond reversal of an acid sensitive, dopamine D4 receptor partial agonist, PD 168077. This reversal provided compounds with excellent potency and improved stability. Systematic evaluation of the substitution on the aryl piperazine portion revealed a significant effect on functional activity. The synthesis and biological activity of these new dopamine D4 agonists is discussed.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.