630382-44-4

Basic information

• Product Name: 7H-Pyrazolo[3,4-c]pyridin-7-one, 1,4,5,6-tetrahydro-1-(4-methoxyphenyl)-3-(trifluoromethyl)-
• CAS NO: 630382-44-4
• Molecular Formula: C14H12F3N3O2
• Molecular Weight: 311.263
• Mol File: 630382-44-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7H-Pyrazolo[3,4-c]pyridin-7-one, 1,4,5,6-tetrahydro-1-(4-methoxyphenyl)-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrazolo[3,4-c]pyridin-7-one, 1,4,5,6-tetrahydro-1-(4-methoxyphenyl)-3-(trifluoromethyl)-(630382-44-4)
• EPA Substance Registry System: 7H-Pyrazolo[3,4-c]pyridin-7-one, 1,4,5,6-tetrahydro-1-(4-methoxyphenyl)-3-(trifluoromethyl)-(630382-44-4)

Safety Data

• Hazardous Substances Data: 630382-44-4(Hazardous Substances Data)

Upstream product

• 207976-92-9 3-chloro-5,6-dihydro-1H-pyridin-2-one 
• 545445-40-7 3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 
• 41419-12-9 3,3-dichloro-piperidin-2-one 
• 675-20-7 piperidin-2-one 
• 116853-79-3 trifluoroacetaldehyde 4-methoxyphenylhydrazone 

Downstream Products

• 630382-45-5 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}cyclopropanecarboxylic acid 
• 630384-47-3 6-{4-[1-(4,5-dihydro-1H-imidazol-2-yl)cyclopropyl]phenyl}-1-(4-methoxyphenyl)-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one 

Relevant articles and documents

HYDRAZINE COMPOUND AS BLOOD COAGULATION FACTOR Xa INHIBITOR

Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a 3-9 membered carbon ring or its phenyl ring, and a 4-10 membered heterocyclic ring or its benzo ring; Y and Z are independently selected from 4-9 membered saturated heterocyclic rings respectively; RI-3 are independently selected from H, F, Cl, Br, I, CN, OH, SH,NH2, CHO, COOH respectively, or selected from C1-10 alkyls or heteroalkyls optionally substituted by R01, C3-10 alkyls ring hydrocarbon groups or heterocyclic hydrocarbon groups, C1-10 alkyls or heteroalkyls substituted by C3-10 ring hydrocarbon groups or heterocyclic hydrocarbon group. The compound can be used as an anticoagulant for treating and preventing thrombotic disorders, and can meet the real needs of selectivity and a potent inhibitor for coagulation Xa.

LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS

The present application descirbes linear chain subtituted monocyclic and byciclic compounds and derivatives thereof of formula (I): P4-P-M-M4 or pharmaceutically acceptable salts from thereof, P-M are rings substituted by a linear group. Compounds of the present invention are useful as inhibitors of trypsin like serine proteases, specifically factor Xa.