63072-14-0

Basic information

• Product Name: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-
• CAS NO: 63072-14-0
• Molecular Formula: C26H20FOP
• Molecular Weight: 398.416
• Mol File: 63072-14-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-(63072-14-0)
• EPA Substance Registry System: Ethanone, 1-(4-fluorophenyl)-2-(triphenylphosphoranylidene)-(63072-14-0)

Safety Data

• Hazardous Substances Data: 63072-14-0(Hazardous Substances Data)

Upstream product

• 603-35-0 triphenylphosphine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 1006-39-9 1-(2-bromo-4-fluorophenyl)ethanone 
• 120302-61-6 Br^(1-)*C₂₆H₂₁FOP⁽¹⁺⁾ 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 1189060-08-9 ethyl (E,E)-6-(4-fluorophenyl)-6-oxohexa-2,4-dienoate 
• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 
• 1256284-90-8 1-(4-fluorophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 1269668-33-8 (2E,7E)-1,9-bis(4-fluorophenyl)nona-2,7-diene-1,9-dione 
• 1422452-55-8 (E)-5-(cyclohexylmethoxy)-3-(3-(4-fluorophenyl)-3-oxoprop-1-enyl)-4H-chromen-4-one 
• 1422452-67-2 (E)-5-(cyclohexylmethoxy)-3-(3-(4-fluorophenyl)-3-hydroxyprop-1-enyl)-4H-chromen-4-one 
• 1619223-37-8 C₂₁H₁₈FNO₄ 
• 1647059-08-2 C₁₇H₂₃FN₂O₂Si 
• 1623752-22-6 5-((tert-butyldimethylsilyl)oxy)-1-(4-fluorophenyl)pent-2-en-1-one 
• 1616777-24-2 (E)-4-diazo-5-(4-fluorophenyl)-5-oxopent-2-enal 
• 1647059-14-0 C₁₁H₉FN₂O₂ 

Relevant articles and documents

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions

The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, we report an "ene"-reductase catalyzed asymmetric hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Four rounds of site saturation mutagenesis were used to access a variant of the "ene"-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles capable of catalyzing a cyclization to furnish β-chiral cyclopentanones with high levels of enantioselectivity. Additionally, wild-type NCR can catalyze intermolecular couplings with precise stereochemical control over the radical termination step. This report highlights the utility for ground-state electron transfers to enable non-natural biocatalytic C-C bond forming reactions.

Copper-Catalyzed N-O Cleavage of α,β-Unsaturated Ketoxime Acetates toward Structurally Diverse Pyridines

The copper-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with 1,3-dicarbonyl compounds for the synthesis of three classes of structurally diverse pyridines has been developed. This method employs 1,3-dicarbonyl compounds as C2 synthons and enables the synthesis of multifunctionalized pyridines with diverse electron-withdrawing groups in moderate to good yields. The mechanistic investigation suggests that the reactions proceed through an ionic pathway.

Organocatalytic Enantioselective Selenosulfonylation of a C-C Double Bond to Form Two Stereogenic Centers in an Aqueous Medium

Organocatalytic selenosulfonylation of the C-C double bond of α,β-unsaturated ketones to construct two contiguous stereogenic centers in an aqueous medium was described. A series of α-selenyl and β-sulfonyl ketones with various functional groups were synthesized in good yields and enantioselectivities with saturated NaCl solution as the solvent. In addition, this protocol had been successfully scaled up to a decagram scale via a simple workup procedure.