63096-06-0Relevant articles and documents
CuII/TEMPO-promoted one-pot synthesis of highly substituted pyrimidines from amino acid esters
Zhou, Nini,Xie, Tao,Li, Zhongle,Xie, Zhixiang
, p. 17311 - 17314 (2014)
A novel, Cu(OAc)2/TEMPO promoted one-step approach for the preparation of fully substituted pyrimi-dines from readily available amino acid esters has been described. In this reaction, the amino acid esters act as the only N-C sources for the construction of corresponding pyrimidines. The mechanism of this process includes oxidative dehydrogenation, the generation of an imine radical, and a formal [3+3] cycloaddition. This methodology proves to be a high atom-economic and straightforward strategy for the synthesis of pyrimidines and diverse substrates which are substituted by various functional groups have been afforded in moderate to good yield.
AMINO ACIDS AS SYNTHONS FOR HETEROCYCLES. FORMATION OF 1,2,4-TRIAZINE DERIVATIVES
Smodis, Janez,Zupet, Rok,Petric, Andrej,Stanovnik, Branko,Tisler, Miha
, p. 393 - 405 (2007/10/02)
Transformation of the amino group of amino acids into an amidine and subsequent treatment with hydrazine leads to 1,2,4-triazine-6(1H)-ones.The method described is a new synthetic approach.Unsaturated amino acids gave imidazol-5-one derivatives after the
