6310-45-8

Basic information

• Product Name: 1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)propane-1,3-dione
• CAS NO: 6310-45-8
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.28
• Mol File: 6310-45-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 451.5°C at 760 mmHg
• Flash Point: 168.7°C
• Density: 1.232g/cm³
• Vapor Pressure: 9.08E-09mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)propane-1,3-dione(6310-45-8)
• EPA Substance Registry System: 1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)propane-1,3-dione(6310-45-8)

Safety Data

• Hazardous Substances Data: 6310-45-8(Hazardous Substances Data)

Usage

Description

1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)propane-1,3-dione, commonly known as curcumin, is a naturally occurring compound derived from the rhizome of the turmeric plant. It is characterized by its vibrant yellow hue and is renowned for its anti-inflammatory and antioxidant properties. Curcumin has demonstrated potential therapeutic benefits for a range of health conditions, such as arthritis, cancer, and neurodegenerative diseases. Its chemical structure allows for interactions with various biological targets, making it a versatile compound with promising pharmaceutical applications.

Uses

Used in Food Industry:
Curcumin is utilized as a natural colorant and flavoring agent in the food industry, adding a distinctive yellow color and unique taste to various products.
Used in Traditional Medicine:
In traditional medicine, curcumin is employed for its anti-inflammatory and antioxidant properties, often used to alleviate symptoms of conditions like arthritis and to support overall health.
Used in Pharmaceutical Applications:
Curcumin is explored as a potential therapeutic agent for various health conditions, including arthritis, cancer, and neurodegenerative diseases, due to its ability to modulate multiple biological pathways involved in these diseases.
Used in Drug Delivery Systems:
Curcumin's potential use in drug delivery systems is being investigated to overcome its poor bioavailability and rapid metabolism, with the aim of enhancing its effectiveness as a pharmaceutical compound.
Used in Treatment of Diabetes and Cardiovascular Disease:
Research into curcumin's potential as a treatment for diabetes, cardiovascular disease, and other ailments is ongoing, with the goal of leveraging its anti-inflammatory and antioxidant properties for therapeutic benefit.

Upstream product

• 606-45-1 2-methoxybenzoic acid methyl ester 
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• 55153-18-9 2-oxo-2-phenylethyl 3-methoxybenzoate 
• 579-75-9 2-Methoxybenzoic acid 

Downstream Products

• 19725-47-4 2'-methoxyflavone 
• 84634-57-1 2-(2'-hydroxyphenyl)-4-(2''-methoxyphenyl)-3H-1,5-benzodiazepine 
• 35244-11-2 2'-hydroxyflavone 
• 1313861-87-8 1-methyl-3-(2'-hydroxyphenyl)-5-(2''-methoxyphenyl)pyrazole 
• 1202243-65-9 C₁₆H₁₄N₂O₂ 
• 1313861-85-6 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole 

Relevant articles and documents

Synthesis, structure and acetylcholinesterase inhibition activity of new diarylpyrazoles

A variety of diarylpyrazole derivatives III-VI were synthesized and structurally characterized using FTIR, 1H and 13C NMR spectroscopy, and in case of compound VIb by X-ray single crystal analysis. The in vitro biological studies rev

Novel Bifunctionalization of Activated Methylene: Base-Promoted Trifluoromethylthiolation of β-Diketones with Trifluoromethanesulfinyl Chloride

A novel bifunctionalization of activated methylene was achieved successfully through the base-promoted trifluoromethylthiolation of β-diketones or β-ketoesters with trifluoromethanesulfinyl chloride. A series of α-trifluoromethylthiolated α-chloro-β-diketones and α-chloro-β-ketoesters were obtained in moderate to good yields under mild conditions. When β-diketones containing a phenyl group with a hydroxyl or amino substituent at the ortho position were used as substrates, intramolecular trifluoromethylthiolation/cyclization reaction took place to give the corresponding cyclic products. Furthermore, the protocol could be extended to perfluoroalkylthiolation with the sodium perfluoroalkanesulfinate/POCl3 system. On the basis of experimental results, plausible mechanisms are proposed.

Synthesis and anti-cancer activities of apigenin derivatives

A novel series of apigenin derivatives with phloroglucinol or resorcinol as raw materials were synthesized according to Baker-Venaktaraman reaction and their in vitro inhibitory activities on colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The results of biological test showed that some of apigenin derivatives possessed stronger anti-cancer activities than apigenin. Compound 6 showed the strongest activity against colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines with IC50 valure of 2.03±0.22 μM, 2.25±0.42 μM, it was better than 5-FU (12.92±0.61 μM, 9.56±0.16 μM), which shows a potezntial compound for colorectal adenocarcinoma and leucocythemia.