6312-02-3

Basic information

• Product Name: 4-methyl-2-phenylpiperidine
• CAS NO: 6312-02-3
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.2701
• Mol File: 6312-02-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 266.8°C at 760 mmHg
• Flash Point: 115.6°C
• Density: 0.938g/cm³
• Vapor Pressure: 0.00845mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: 4-methyl-2-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-phenylpiperidine(6312-02-3)
• EPA Substance Registry System: 4-methyl-2-phenylpiperidine(6312-02-3)

Safety Data

• Hazardous Substances Data: 6312-02-3(Hazardous Substances Data)

Upstream product

• 2840-61-1 3-methyl-5-oxo-5-phenylpentanoic acid 
• 591-51-5 phenyllithium 
• 626-58-4 4-methylpiperidin 
• 3475-21-6 4-methyl-2-phenylpyridine 
• 4926-28-7 2-Bromo-4-picoline 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

PIPERIDIN-1- YL-N-PYRYDI NE-3-YL-2-OXOACET AM IDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MT A-ACCUMULATING CANCERS

Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade

We have developed a method for a B(C6F5)3-catalyzed hydroboration/hydrogenation cascade reduction of pyridines. The method was particularly effective for 2,3-disubstituted pyridines, which generated piperidines in high yields with high cis selectivity. Mechanistic studies indicated that the pyridine substrates and the piperidine products sequentially acted as bases in cooperation with B(C6F5)3to split H2. The broad functional group tolerance of the method allowed its use for the synthesis of some biologically active molecules.