6312-12-5

Basic information

• Product Name: 1-(2-fluorobenzyl)-1-[3-(1H-imidazol-1-yl)propyl]-3-phenylurea
• CAS NO: 6312-12-5
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 352.4053
• Mol File: 6312-12-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 617.8°C at 760 mmHg
• Flash Point: 327.5°C
• Density: 1.17g/cm³
• Vapor Pressure: 3.41E-15mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-(2-fluorobenzyl)-1-[3-(1H-imidazol-1-yl)propyl]-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluorobenzyl)-1-[3-(1H-imidazol-1-yl)propyl]-3-phenylurea(6312-12-5)
• EPA Substance Registry System: 1-(2-fluorobenzyl)-1-[3-(1H-imidazol-1-yl)propyl]-3-phenylurea(6312-12-5)

Safety Data

• Hazardous Substances Data: 6312-12-5(Hazardous Substances Data)

Usage

Functional groups

Urea derivative, fluorobenzyl group, imidazole ring, and phenyl group

Structural features

The urea core is attached to a 2-fluorobenzyl group, a 3-(1H-imidazol-1-yl)propyl group, and a phenyl group

Potential applications

Medicinal chemistry, targeting imidazole receptors, and as an inhibitor of urease enzymes

Significance

Unique structural features make it a candidate for further investigation in drug discovery and development

Upstream product

• 100-69-6 2-vinylpyridine 
• 62-53-3 aniline 
• 1945-84-2 2-ethynylpyridine 
• 142-04-1 aniline hydrochloride 
• 109-06-8 α-picoline 
• 103-74-2 2-(2-Hydroxyethyl)pyridine 
• 64-19-7 acetic acid 

Downstream Products

• 6312-26-1 N-methyl-N-(2-[2]pyridyl-ethyl)-aniline 
• 377076-43-2 phenyl-(2-pyridin-2-yl-ethyl)-trimethylsilanyl-amine 
• 1384522-73-9 N-[2-(pyridine-2-yl)ethyl]-N-( pyridine-2-ylmethyl)aniline 
• 42181-26-0 N-phenyl-N-(2-(pyridin-2-yl)ethyl)benzamide 

Relevant articles and documents

Introverted Br?nsted acid cavitands for selective conjugate addition reactions

Four new quinoxaline-spanned cavitands having a diester hydrogen phosphate group were successfully synthesised. These phosphorous derivatives were applied in Br?nsted acid-assisted catalytic conjugate addition reactions. The results were ranked with the c

The catalytic effect of anion-exchanged supported ionic liquid on aza-Michael-type addition

Abstract: An effective synthesis of anion-exchanged supported ionic liquids using diatomaceous earth as solid support and its catalytic effect on the aza-Michael-type addition is described. Anionic polytungstophosphate and bisulfate ion are used in the anion-exchange step in catalyst design. In addition, the aza-Michael-type addition of various amines to 2- and 4-vinyl pyridine was examined in this article. The catalytic system can be separated from the reaction mixture and recycled in subsequent reactions. The structure of anion-exchanged supported ionic liquid on diatomaceous earth was studied by XRD, FT-IR, SEM, TGA and BET techniques. The structure of organic products was determined by 1HNMR, 13CNMR, FTIR, CHN and MASS spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].

Superelectrophilic amidine dications: Dealkylation by triflate anion

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