6314-58-5

Basic information

• Product Name: (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one
• Synonyms: (2E)-3-Phenyl-1-(pyridin-4-yl)prop-2-en-1-one; 2-propen-1-one, 3-phenyl-1-(4-pyridinyl)-, (2E)-
• CAS NO: 6314-58-5
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.2432
• Mol File: 6314-58-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 370°C at 760 mmHg
• Flash Point: 185.1°C
• Density: 1.143g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one(6314-58-5)
• EPA Substance Registry System: (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one(6314-58-5)

Safety Data

• Hazardous Substances Data: 6314-58-5(Hazardous Substances Data)

Usage

Description

(2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one, also known as 3-phenyl-2-styryl-4(1H)-pyridinone, is a chemical compound with the molecular formula C16H13NO. It is a yellow crystalline solid with a molecular weight of 235.28 g/mol. (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is recognized for its potential in pharmaceutical research and drug development due to its biological activities, such as anti-inflammatory and anti-tumor properties.

Uses

Used in Pharmaceutical Research and Drug Development:
(2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is used as a building block in organic synthesis and as a reagent in chemical reactions for its potential to contribute to the development of new pharmaceuticals. Its anti-inflammatory and anti-tumor properties make it a promising candidate for the creation of medications targeting various diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is utilized as a key component to construct more complex organic molecules. Its unique structure allows it to be a versatile building block, facilitating the synthesis of a wide range of compounds.
Used in the Synthesis of Heterocyclic Compounds:
(2E)-3-phenyl-1-pyridin-4-ylprop-2-en-1-one is also used in the synthesis of heterocyclic compounds, which are known for their diverse range of pharmacological applications. Its involvement in the creation of these compounds opens up opportunities for the discovery of new drugs with potential therapeutic benefits.

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 100-52-7 benzaldehyde 
• 173681-56-6 1-(4-(pyridin-2-yl)phenyl)ethanone 
• 872-85-5 pyridine-4-carbaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 1111313-01-9 C₂₈H₂₂N₂O₂ 
• 1111313-09-7 C₂₈H₂₂N₂O₂ 
• 1111313-05-3 C₂₈H₂₂N₂O₂ 
• 19847-46-2 4-azachalcone hydrochloride 
• 1355253-90-5 3-(4-chlorophenyl)-1-{5-phenyl-3-(4-pyridyl)-4,5-dihydro-1H-pyrazol-1-yl}isoquinoline 

Relevant articles and documents

High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones

The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.

A regioselective and convenient one-pot multicomponent synthesis of 9-amino-3,5-diaryl-4,9-dihydro-5H-[1,2,4]triazolo[5,1-c][1,2,4]triazepine-8-thiol

An efficient and environment-friendly procedure for the synthesis of a new series of nitrogen bridge-head [1,2,4]triazolo[5,1-c][1,2,4]triazepine derivatives through one-pot three-component reaction of polyfunctional triazole with aromatic aldehydes and acetophenone derivatives using alcoholic sodium hydroxide solution. The same new products were prepared in classical route through reaction of triazole with the corresponding chalcones under the same conditions.

Iron-oxide nanoparticles mediated cyclization of 3-(4-chlorophenyl)-1- hydrazinylisoquinoline to 1-(4,5-dihydropyrazol-1-yl)isoquinolines

Iron-oxide nanoparticles were obtained using chitosan templates and their crystalline character and particle size have been confirmed through powder x-ray diffraction and transmission electron microscopy measurements. The particle sizes were found to be 10-25 nm. The diversified chalcones 2 were reacted with 1-hydrazinylisoquinoline 1 in the presence of iron-oxide nanoparticles to the corresponding pyrazolines 3a-j in high yield and purity. The pyrazolines were characterized by spectroscopic techniques. Springer Science+Business Media B.V. 2011.