631416-71-2

Basic information

• Product Name: (3S,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1,3-dimethyl-3-trimethylsilanyloxy-pyrrolidin-2-one
• Synonyms: (3S,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1,3-dimethyl-3-trimethylsilanyloxy-pyrrolidin-2-one
• CAS NO: 631416-71-2
• Molecular Weight: 758.361
• Mol File: 631416-71-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3S,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1,3-dimethyl-3-trimethylsilanyloxy-pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1,3-dimethyl-3-trimethylsilanyloxy-pyrrolidin-2-one(631416-71-2)
• EPA Substance Registry System: (3S,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1,3-dimethyl-3-trimethylsilanyloxy-pyrrolidin-2-one(631416-71-2)

Safety Data

• Hazardous Substances Data: 631416-71-2(Hazardous Substances Data)

Upstream product

• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 66774-80-9 (S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate 
• 50-14-6 Calciferol 
• 161055-41-0 (3S,5R)-3,5-bis(t-butyldimethylsilyloxy)octa-1-en-7-yne 
• 631416-66-5 (3S,5S)-5-((R)-2-{(1R,3aR,7aR)-4-[1-Bromo-meth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1,3-dimethyl-3-trimethylsilanyloxy-pyrrolidin-2-one 
• 631416-67-6 (2S,4S)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxane 
• 631416-63-2 (3S,5S)-3-{(R)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-propyl}-2,5-dimethyl-isoxazolidine-5-carboxylic acid methyl ester 
• 631416-65-4 (3S,5S)-1,3-Dimethyl-5-[(R)-2-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-propyl]-3-trimethylsilanyloxy-pyrrolidin-2-one 
• 631416-64-3 (3S,5S)-3-Hydroxy-5-[(R)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyl-octahydro-inden-1-yl)-propyl]-1,3-dimethyl-pyrrolidin-2-one 
• 631416-75-6 (3S,5S)-3-Hydroxy-1,3-dimethyl-5-[(R)-2-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-propyl]-pyrrolidin-2-one 
• 710308-01-3 C₂₁H₄₁NO₂Si 
• 631416-69-8 (3S)-3-((methoxyphenyl)methyl)oxy-5-hydroxy-1-octen-7-yne 
• 631416-68-7 (3S)-3-((4-methoxyphenyl)methyl)oxy-5-formyl-1-pentene 

Relevant articles and documents

Practical synthesis and evaluation of the biological activities of 1α,25-dihydroxyvitamin D3 antagonists, 1α,25- dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis

A practical synthetic route to novel vitamin D antagonists of DLAM (1α,25-dihydroxyvitamin D3-26,23-lactam) was developed from vitamin D2 via the 1,3-dipolar cycloaddition reaction as a key step. Six DLAM derivatives (24 compounds) w

Novel heteroatom-containing vitamin D3 analogs: Efficient synthesis of 1α,25-dihydroxyvitamin D3-26,23-lactam

Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains - so-called vitamin D3 lactam analogs - via 1,3-dipolar cycloaddition reaction as a key step.