63142-71-2 Usage
Description
Ribavirin 5'-triphosphate is a metabolite of ribavirin, a nucleoside analog with antiviral properties. It plays a crucial role in inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the synthesis of guanine nucleotides.
Uses
Used in Antiviral Applications:
Ribavirin 5'-triphosphate is used as an antiviral agent for its ability to inhibit the replication of various viruses. It is particularly effective against RNA and DNA viruses, including respiratory syncytial virus, influenza, and hepatitis C virus.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ribavirin 5'-triphosphate is used as a key component in the development of antiviral medications. Its incorporation into drug formulations helps in the treatment and prevention of viral infections, contributing to improved public health outcomes.
Used in Research and Development:
Ribavirin 5'-triphosphate is also utilized in research settings to study the mechanisms of viral replication and the development of antiviral resistance. This knowledge aids in the design of more effective antiviral therapies and strategies to combat emerging viral threats.
Check Digit Verification of cas no
The CAS Registry Mumber 63142-71-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,4 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63142-71:
(7*6)+(6*3)+(5*1)+(4*4)+(3*2)+(2*7)+(1*1)=102
102 % 10 = 2
So 63142-71-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H15N4O14P3/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(24-8)1-23-28(19,20)26-29(21,22)25-27(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H,19,20)(H,21,22)(H2,16,17,18)/t3-,4-,5-,8-/m1/s1
63142-71-2Relevant articles and documents
Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity
Moriyama, Kei,Suzuki, Tetsuya,Negishi, Kazuo,Graci, Jason D.,Thompson, Corinne N.,Cameron, Craig E.,Watanabe, Masahiko
, p. 159 - 166 (2008/09/18)
One of the possible mechanisms of antiviral action of ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, 1) is the accumulation of mutations in viral genomic RNA. The ambiguous incorporation of 5′-triphosphate of ribavirin (RTP, 8) by a viral RNA-dependent RNA polymerase (RdRp) is a key step of the mutation induction. We synthesized three ribavirin analogues that possess hydrophobic groups, 4-iodo-1-β-D- ribofuranosylpyrazole-3-carboxamide (7a), 4-propynyl-1-β-D- ribofuranosylpyrazole-3-carboxamide (7b), and 4-phenylethynyl-1-β-D- ribofuranosylpyrazole-3-carboxamide (7c), and the corresponding triphosphates (9a, 9b, and 9c, respectively). Steady-state kinetics analysis of the incorporation of these triphosphate analogues by a poliovirus RdRp, 3D pol, revealed that while the incorporation efficiency of 9a was comparable to RTP, 9b and 9c showed lower efficiency than RTP. Antipolioviral activity of 7a and 7b was much more moderate than ribavirin, and 7c showed no antipolioviral activity. Effects of substituting groups on the incorporation efficiency by 3Dpol and a strategy for a rational design of more active ribavirin analogues are discussed.
