6318-41-8

Basic information

• Product Name: 5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione
• CAS NO: 6318-41-8
• Molecular Formula: C₁₁H₇NO₄S
• Molecular Weight: 249.2426
• Mol File: 6318-41-8.mol
• Article Data: 4

Chemical Properties

• Density: 1.595g/cm³
• Refractive Index: 1.731
• CAS DataBase Reference: 5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione(6318-41-8)
• EPA Substance Registry System: 5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione(6318-41-8)

Safety Data

• Hazardous Substances Data: 6318-41-8(Hazardous Substances Data)

Usage

General Description

5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione is a chemical compound with potential pharmaceutical applications. It is a thiazolidinedione derivative, which is known for its insulin-sensitizing and antidiabetic properties. The presence of the 1,3-benzodioxol-5-ylmethylidene group in the molecule suggests potential bioactivity due to its association with benzodioxole compounds, which have shown various pharmacological activities. This chemical compound may have implications in the treatment of diabetes and other related metabolic disorders, making it an important molecule in pharmaceutical research and development.

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 120-57-0 piperonal 

Relevant articles and documents

Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

A new series of thiazolidinedione derivatives were synthesized and evaluated for in vitro α-glucosidase inhibition and anticancer activities. Compounds 3d, 3e and 3j showed potential α-glucosidase inhibition with IC50 values ranging between 0.1 and 0.3 μg/ml whereas compounds 3i, 3j and 3k have showed better anticancer activity towards human cancer cell lines IMR-32 (neuroblastoma), Hep-G2 (hepatoma) and MCF-7 (breast). Molecular docking studies revealed compounds 3d, 3e and 3j are potent inhibitors of α-glucosidase and also showed compliance with standard parameters of drug likeness.

Synthesis and structure of new 5-(arylidene)-3-(4-methylbenzoyl) thiazolidine-2,4-diones

(Chemical Equation Presented) The derivatives of 5-substituted-2,4- thiazolidinedione have a broad spectrum of biological activities. In this article, new 5-(arylidene)-3-(4-methylbenzoyl)thiayolidine-2,4-diones 3a-k, with arylidene groups such as 4-pheny