6318-44-1

Basic information

• Product Name: N~2~,N~2~-dimethylglycinamide
• CAS NO: 6318-44-1
• Molecular Formula: C₄H₁₀N₂O
• Molecular Weight: 102.135
• Mol File: 6318-44-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 204.8°C at 760 mmHg
• Flash Point: 77.7°C
• Density: 0.995g/cm³
• Vapor Pressure: 0.259mmHg at 25°C
• Refractive Index: 1.455
• CAS DataBase Reference: N~2~,N~2~-dimethylglycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N~2~,N~2~-dimethylglycinamide(6318-44-1)
• EPA Substance Registry System: N~2~,N~2~-dimethylglycinamide(6318-44-1)

Safety Data

• Hazardous Substances Data: 6318-44-1(Hazardous Substances Data)

Usage

General Description

N,N-dimethylglycinamide is a chemical compound with the molecular formula C4H10N2O and the systematic name N,N-dimethylglycinamide. It is a derivative of glycine, a simple amino acid, and is commonly used as a precursor in the synthesis of pharmaceuticals and specialty chemicals. N,N-dimethylglycinamide is a white crystalline solid that is soluble in water and organic solvents. It has a variety of applications in the pharmaceutical and chemical industries, including as a building block for the synthesis of pharmaceutical compounds, as a stabilizer for metal ions in chemical reactions, and as an additive in cosmetic and personal care products. Overall, N,N-dimethylglycinamide is a versatile and important chemical with a range of industrial and commercial uses.

Upstream product

• 926-64-7 N,N-Dimethylamino acetonitrile 
• 124-40-3 dimethyl amine 
• 79-07-2 Chloroacetamide 
• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 
• 683-57-8 bromo-acetic acid amide 

Downstream Products

• 115933-03-4 1-[(dimethylamino)acetyl]-1,4-dihydro-4,4-diphenylpyridine 
• 1467-79-4 NCNMe₂ 
• 1345847-89-3 N-(4-(2-(2-(dimethylamino)acetamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1365989-39-4 N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(dimethylamino)acetamide 

Relevant articles and documents

Substrate-Specific Heterogeneous Catalysis of CeO2 by Entropic Effects via Multiple Interactions

Achieving complete substrate specificity through multiple interactions like an enzyme is one of the ultimate goals in catalytic studies. Herein, we demonstrate that multiple interactions between the CeO2 surface and substrates are the origin of substrate-specific hydration of nitriles in water by CeO2, which is exclusively applicable to the nitriles with a heteroatom (N or O) adjacent to the α-carbon of the CN group but is not applicable to the other nitriles. Kinetic studies reveal that CeO2 reduces the entropic barrier (TΔS?) for the reaction of the former reactive substrate, leading to 107-fold rate enhancement compared with the latter substrate. Density functional theory (DFT) calculations confirmed multiple interaction of the reactive substrate with CeO2, as well as preferable approximation and alignment of the nitrile group of the substrate to the active OH group on CeO2 surface. This can lead to the reduction of the entropic barrier. This is the first example of an entropy-driven substrate-specific catalysis of a nonporous metal oxide surface, which will provide a new design strategy for enzyme-inspired synthetic catalysts.