63187-91-7

Basic information

• Product Name: Menthone 1,2-glycerol ketal
• Synonyms: L-MENTHONE-1,2-GLYCERYL KETAL;FEMA 3807;MENTHONE GLYCERIN ACETAL;1,4-Dioxaspiro4.5decane-2-methanol, 9-methyl-6-(1-methylethyl)-;9-Methyl-6-(1-methylethyl)-1,4-dioxaspiro-[4,5]decan-2-methanol;6-ISOPROPYL-9-METHYL-1,4-DIOXASPIRO[4.5]DECANE-2-METHANOL;Menthone 1,2-glycerol ketal;2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane
• CAS NO: 63187-91-7
• Molecular Formula: C₁₃H₂₄O₃
• Molecular Weight: 228.33
• EINECS: 408-200-3
• Mol File: 63187-91-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 322.9 ºC at 760 mmHg
• Flash Point: 159.7 ºC
• Appearance: clear colourless viscous liquid
• Density: 1.04 g/cm³
• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.488
• PKA: 14.21±0.10(Predicted)
• Water Solubility: 1.2g/L at 20℃
• CAS DataBase Reference: Menthone 1,2-glycerol ketal(CAS DataBase Reference)
• NIST Chemistry Reference: Menthone 1,2-glycerol ketal(63187-91-7)
• EPA Substance Registry System: Menthone 1,2-glycerol ketal(63187-91-7)

Safety Data

• Hazard Codes: Xi
• Statements: 38-41-52/53
• Safety Statements: 26-37/39-61
• Hazardous Substances Data: 63187-91-7(Hazardous Substances Data)

Usage

Description

Menthone 1,2-glycerol ketal is a colorless, viscous liquid that is a derivative of menthol. It is known for its cooling effect on the skin or mucosa and has a mint, menthol taste. Menthone 1,2-glycerol ketal can be naturally obtained or synthetically manufactured and is prepared by acetalization of l-menthone with glycerine.

Uses

Used in Pharmaceutical Industry:
Menthone 1,2-glycerol ketal is used as a therapeutic agent containing a TRPM8 agonist for treating gastrointestinal disorders and abdominal pain. It provides relief by targeting the cold-sensitive TRPM8 receptors, which are involved in the sensation of cold and pain.
Used in Cosmetics and Personal Care Industry:
Menthone 1,2-glycerol ketal is used as an ingredient in cosmetic preparations for its cooling effect on the skin. It is particularly useful in products designed to provide a refreshing and cooling sensation, such as lotions, creams, and gels.
Used in Flavor and Fragrance Industry:
Menthone 1,2-glycerol ketal is used as a flavoring agent for its clean, crisp, and cool taste. It has a taste threshold value between 5 to 100 ppm, where it exhibits a coolness that starts low but grows, accompanied by a slight tingling or burning sensation. The flavor character is lingering and cumulative in effect.
Used in Aromatherapy:
Menthone 1,2-glycerol ketal is used in aromatherapy for its refreshing and cooling properties. Its aroma characteristics at 10% concentration show little or no odor, making it suitable for blending with other essential oils to create custom fragrances or for use in diffusers to provide a soothing and invigorating atmosphere.

Trade name

Frescolate MGA (Symrise)

InChI:InChI=1/C13H24O3/c1-9(2)12-5-4-10(3)6-13(12)15-8-11(7-14)16-13/h9-12,14H,4-8H2,1-3H3

Downstream Products

• 10458-14-7 Menthone