6319-45-5

Basic information

• Product Name: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE
• Synonyms: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE;N-(4-NITROPHENYLSULFONYL)METHYLAMINE;Benzenesulfonamide, N-methyl-4-nitro-;Inchi=1/C7H8N2o4S/C1-8-14(12,13)7-4-2-6(3-5-7)9(10)11/H2-5,8H,1h
• CAS NO: 6319-45-5
• Molecular Formula: C₇H₈N₂O₄S
• Molecular Weight: 216.21442
• Mol File: 6319-45-5.mol
• Article Data: 37

Chemical Properties

• Melting Point: 105-106 °C
• Boiling Point: 377.7 °C at 760 mmHg
• Flash Point: 182.3 °C
• Appearance: /
• Density: 1.423 g/cm³
• Vapor Pressure: 6.6E-06mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.31±0.30(Predicted)
• CAS DataBase Reference: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE(6319-45-5)
• EPA Substance Registry System: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE(6319-45-5)

Safety Data

• Hazardous Substances Data: 6319-45-5(Hazardous Substances Data)

Usage

General Description

N1-Methyl-4-nitrobenzene-1-sulfonamide, also known as 4-Nitrobenzene-1-sulfonamide, is a chemical compound featuring a molecular structure that contains benzene sulfonamide unit with an additional nitro group and a methyl group. It is a nitrogen and sulfur organic compound that commonly appears as a white solid powder at room temperature. As a synthesized compound, it has a range of specific applications primarily within the field of organic chemistry for the production of various drugs and pharmaceuticals. However, like many chemical substances, it must be handled properly to prevent any potential hazards or harm to health, due to its potentially toxic properties. Its molecular formula is C7H8N2O4S.

InChI:InChI=1/C7H8N2O4S/c1-8-14(12,13)7-4-2-6(3-5-7)9(10)11/h2-5,8H,1H3

Upstream product

• 74-89-5 methylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 86674-15-9 C₇H₇N₃O₆S 
• 210820-72-7 4-nitro-benzenesulfonic acid-(methyl-nitroso-amide) 
• 100-61-8 N-methylaniline 
• 74-88-4 methyl iodide 
• 945014-90-4 N-methyl-N-nosyl-L-alanyldiazomethane 
• 120-94-5 1-Methylpyrrolidine 
• 108-30-5 succinic acid anhydride 
• 14533-84-7 pentafluorophenyl trifloroacetate 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 593-51-1 methylamine hydrochloride 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 67-56-1 methanol 

Downstream Products

• 210820-72-7 4-nitro-benzenesulfonic acid-(methyl-nitroso-amide) 
• 86674-15-9 C₇H₇N₃O₆S 
• 27831-90-9 N-Acetylderivative of 4-nitrobenzenesulfonamide-N-methyl 
• 177536-49-1 N-Methyl-4-nitrosobenzolsulfonsaeureamid 
• 1709-52-0 N-methyl-4-aminobenzenesulfonamide 
• 69751-90-2 4'-chloro-N-methyl-4-nitrobenzenesulfonanilide 
• 211676-02-7 N-methyl-4-nitro-N-(p-tolyl)benzenesulfonamide 
• 211676-01-6 N-methyl-N-nosyl-m-toluidine 
• 211676-00-5 N-methyl-N-nosyl-o-toluidine 
• 64999-94-6 N-methyl-N-phenyl-4-nitrobenzene sulphonamide 
• 164032-14-8 N-chloromethyl-N-methyl-4-nitro-benzenesulfonamide 
• 177536-55-9 4-Formyl-2-methoxyazobenzol-4'-(N-methylsulfonsaeureamid) 
• 177536-69-5 4-(1'',3''Dioxolan-2''-yl)-2-methoxyazobenzol-4'-(N-methylsulfonsaeureamid) 
• 177536-70-8 4-(1'',3''Dioxolan-2''-yl)-2-methoxyazobenzol-4'-(N-allyl-N-methylsulfonsaeureamid) 

Relevant articles and documents

Controlled anchoring of (Phenylureido)sulfonamide-based receptor moieties: An impact of binding site multiplication on complexation properties

The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and1H-NMR in classical or competitive titration mode, the attachment

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Arylation and alkenylation of activated alkyl halides using sulfonamides

A variety of quaternary aryl amino acid derivatives can be synthesised using tandem SN2/Smiles rearrangement chemistry involving aryl sulfonamides and α-chloro carbonyl compounds. The reaction harnesses a sulfur dioxide extrusion pathway to construct a C-N and C-Caryl bond under simple conditions with no requirement for organometallics or transition metal catalysts. The reaction is also successful for alkenyl sulfonamides, producing sterically congested quaternary alkene amino acid derivatives.