6320-26-9

Basic information

• Product Name: 1-(3-chloropropyl)-4-(3-methylphenyl)piperazine
• CAS NO: 6320-26-9
• Molecular Formula: C₁₄H₂₁ClN₂
• Molecular Weight: 252.7829
• Mol File: 6320-26-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 384.2°C at 760 mmHg
• Flash Point: 186.2°C
• Density: 1.077g/cm³
• Vapor Pressure: 4.16E-06mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 1-(3-chloropropyl)-4-(3-methylphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloropropyl)-4-(3-methylphenyl)piperazine(6320-26-9)
• EPA Substance Registry System: 1-(3-chloropropyl)-4-(3-methylphenyl)piperazine(6320-26-9)

Safety Data

• Hazardous Substances Data: 6320-26-9(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivative

Structure

Substituted phenyl ring and a chloropropyl group attached to the piperazine nitrogen atom

Medicinal use

Psychoactive drug

Potential treatments

Depression, anxiety, and schizophrenia

Research applications

Biochemical and pharmacological studies to understand effects on the central nervous system

Neurotransmitter interactions

Serotonin and dopamine receptors

Therapeutic potential

Possible future uses in medicine

Psychoactive effects

May have potential for abuse

Regulation

Requires careful consideration and regulation due to psychoactive properties

Upstream product

• 41186-03-2 1-(3-Methylphenyl)piperazine 
• 109-70-6 1.3-chlorobromopropane 
• 7511-73-1 1-(3-hydroxy-n-propyl)-4-(3-methylphenyl)piperazine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 119696-36-5 1-(4-phenyl-piperazino)-3-(4-m-tolyl-piperazino)-propane 
• 116030-52-5 1-(4-m-tolyl-piperazino)-3-(4-p-tolyl-piperazino)-propane 
• 6320-28-1 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 6320-29-2 1-[4-(4-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 116030-90-1 1-(4-m-tolyl-piperazino)-3-(4-o-tolyl-piperazino)-propane 
• 114694-59-6 1-[4-(2-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 91532-14-8 3-[3-(4-m-Tolyl-piperazin-1-yl)-propyl]-3H-benzo[d][1,2,3]triazin-4-one 
• 103076-65-9 2-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-benzaldehyde 
• 103074-42-6 2-{2-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide 

Relevant articles and documents

Synthesis of 2-phenylthiazolidine derivatives as cardiotonic agents. II. 2-(Phenylpiperazinoalkoxyphenyl)thiazolidine-3-thiocarboxami des and the corresponding carboxamides

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N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure

A piperazine derivative of the formula: STR1 wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R3 CO--(wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), cycloalkyl (C3-6), alkenyl (C2-5), alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.