6323-09-7 Usage
Description
Trazodone IMpurity H, also known as 1,3-Bis-[4-(3-chlorophenyl)piperazin-1-yl]propane, is an impurity found in Trazodone (T718500), a widely prescribed medication for the treatment of major depressive disorder and anxiety disorders. As an impurity, it is essential to monitor and control its presence in the final drug product to ensure safety, efficacy, and quality.
Uses
Used in Pharmaceutical Industry:
Trazodone IMpurity H is used as a reference standard for quality control and analytical testing in the pharmaceutical industry. It helps in the identification, quantification, and control of impurities in Trazodone drug products, ensuring that they meet the required safety and efficacy standards.
Additionally, Trazodone IMpurity H can be used in research and development for the synthesis and optimization of Trazodone and its analogs, contributing to the discovery of new therapeutic agents with improved pharmacological properties and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 6323-09-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,2 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6323-09:
(6*6)+(5*3)+(4*2)+(3*3)+(2*0)+(1*9)=77
77 % 10 = 7
So 6323-09-7 is a valid CAS Registry Number.
6323-09-7Relevant articles and documents
Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT(1A) serotonin receptor ligands
Caliendo, Giuseppe,Fiorino, Ferdinando,Grieco, Paolo,Perissutti, Elisa,Santagada, Vincenzo,Severino, Beatrice,Bruni, Giancarlo,Romeo, Maria Rosaria
, p. 533 - 538 (2007/10/03)
A series of novel 1,2,3-benzotriazin-4-one derivatives was prepared and evaluated as ligands for 5-HT receptors. Radioligand binding assays proved that the majority of the novel compounds behaved as good to excellent ligands at the 5-HT(1A) receptor, some of which were selective with respect 5-HT(2A) and 5-HT(2C) receptors. Six analogues (1a, 2a, 2b, 2c, 2e and 2i) were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1-, α2-adrenergic receptors. A o-OCH3 derivative (2e) bound at 5-HT(1A) sites with subnanomolar affinity (IC50=0.059 nM) and shows high selectivity over all considered receptors and may offer a new lead for the development of therapeutically efficacious agents. Copyright (C) 2000 Elsevier Science Ltd.