63242-12-6

Basic information

• Product Name: (3'-fluorobiphenyl-4-yl)phenylmethanone
• Synonyms: (3'-fluorobiphenyl-4-yl)phenylmethanone
• CAS NO: 63242-12-6
• Molecular Weight: 276.31
• Mol File: 63242-12-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3'-fluorobiphenyl-4-yl)phenylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3'-fluorobiphenyl-4-yl)phenylmethanone(63242-12-6)
• EPA Substance Registry System: (3'-fluorobiphenyl-4-yl)phenylmethanone(63242-12-6)

Safety Data

• Hazardous Substances Data: 63242-12-6(Hazardous Substances Data)

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 1137-42-4 4-Hydroxybenzophenone 
• 2367-22-8 3-fluorobiphenyl 
• 98-88-4 benzoyl chloride 

Downstream Products

• 63242-41-1 4'-(Chloro-phenyl-methyl)-3-fluoro-biphenyl 
• 63242-22-8 (3'-Fluoro-biphenyl-4-yl)-phenyl-methanol 

Relevant articles and documents

The Barbier-Grignard-Type Arylation of Ketones and Unexpected Cross-Coupling of Phenolic Ketones using Unactivated Aryl Bromides

A novel, highly versatile and efficient method has been developed for the Barbier-Grignard-type arylation of ketones and an unexpected cross-coupling of phenolic ketones was observed using unactivated bromides and magnesium in tetrahydrofuran/toluene at 96°C promoted by multicatalysts of cupric bromide (15 mol%), bismuth chloride (5 mol%) and silver bromide (10 mol%). The substituent and electronic effects on the reaction have been discussed. High yields of arylation and cross-coupling have been attained under mild conditions. A novel reasonable mechanism involving a quinone intermediate is proposed. The high chemical selectivity in the cross-coupling to the hydroxy group of phenolic ketones should help ketones find new applications.