6327-47-5

Basic information

• Product Name: N-(2,3-dichlorophenyl)formamide
• CAS NO: 6327-47-5
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.0267
• Mol File: 6327-47-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 359.5°C at 760 mmHg
• Flash Point: 171.2°C
• Density: 1.46g/cm³
• Vapor Pressure: 2.37E-05mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: N-(2,3-dichlorophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dichlorophenyl)formamide(6327-47-5)
• EPA Substance Registry System: N-(2,3-dichlorophenyl)formamide(6327-47-5)

Safety Data

• Hazardous Substances Data: 6327-47-5(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 608-27-5 2,3-dichloroaniline 
• 2258-42-6 formyl acetic anhydride 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 2666-78-6 2,3-dichlorophenyl isocyanide dichloride 
• 65078-77-5 2,3-dichloro-6-nitroaniline 
• 69951-03-7 2,3-dichloro-4-nitroaniline 
• 104310-89-6 (2,3-Dichloro-phenyl)-phosphoramidic acid diethyl ester 
• 56978-58-6 4-Amino-2,3-dichloro-benzenesulfonic acid 
• 105565-53-5 2,3-dichloro-4-nitrobenzenesulphonic acid 
• 105547-67-9 4-(5-Amino-3-methyl-1-phenyl-1H-pyrazol-4-ylazo)-2,3-dichloro-benzenesulfonic acid 
• 105548-07-0 2,3-Dichloro-4-(4,6-diamino-2-ethylsulfanyl-pyrimidin-5-ylazo)-benzenesulfonic acid 
• 105547-88-4 4-(4-Amino-2-diethylamino-6-methyl-pyrimidin-5-ylazo)-2,3-dichloro-benzenesulfonic acid 
• 105548-26-3 4-(2-Acetylamino-4-diethylamino-phenylazo)-2,3-dichloro-benzenesulfonic acid 
• 245539-09-7 2,3-dichlorophenyl isocyanide 

Relevant articles and documents

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.