6328-61-6 Usage
Description
(diphenylmethyl)(trimethyl)silane, also known as DPTS, is a silane compound that features a silicon atom bonded to three methyl groups and a diphenylmethyl group. It is a colorless liquid with high reactivity and flammability, making it a versatile reagent in organic synthesis.
Uses
Used in Organic Synthesis:
(diphenylmethyl)(trimethyl)silane is used as a reagent for the introduction of the trimethylsilyl group in various organic reactions. It aids in the formation of carbon-carbon bonds and the protection of functional groups, enhancing the efficiency and selectivity of synthetic processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (diphenylmethyl)(trimethyl)silane is utilized as a protecting group for certain functional groups in drug molecules, facilitating their synthesis and purification.
Used in Silicone Polymer Production:
(diphenylmethyl)(trimethyl)silane is employed as a building block in the production of silicone polymers, which are essential materials in various applications, including medical devices, sealants, and coatings.
Used as a Crosslinking Agent in Resins and Plastics:
In the plastics and resins manufacturing industry, (diphenylmethyl)(trimethyl)silane is used as a crosslinking agent. It helps improve the mechanical properties, thermal stability, and durability of the final products.
Safety and Handling:
Due to the reactivity and potential hazards associated with (diphenylmethyl)(trimethyl)silane, it is crucial to follow proper handling and storage protocols to ensure safety and prevent accidents. This includes using appropriate containment, ventilation, and protective equipment during its use in laboratories and industrial settings.
Check Digit Verification of cas no
The CAS Registry Mumber 6328-61-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,2 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6328-61:
(6*6)+(5*3)+(4*2)+(3*8)+(2*6)+(1*1)=96
96 % 10 = 6
So 6328-61-6 is a valid CAS Registry Number.
6328-61-6Relevant articles and documents
Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage
Balakrishnan, Venkadesh,Murugesan, Vetrivelan,Chindan, Bincy,Rasappan, Ramesh
, p. 1333 - 1338 (2021/02/20)
Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.
Rhodium-catalyzed silylation and intramolecular arylation of nitriles via the silicon-assisted cleavage of carbon-cyano bonds
Tobisu, Mamoru,Kita, Yusuke,Ano, Yusuke,Chatani, Naoto
supporting information; experimental part, p. 15982 - 15989 (2009/05/16)
A rhodium-catalyzed silylation reaction of carbon - cyano bonds using disilane has been developed. Under these catalytic conditions, carbon-cyano bonds in aryl, alkenyl, allyl, and benzyl cyanides bearing a variety of functional groups can be silylated. The observation of an enamine side product in the silylation of benzyl cyanides and related stoichiometric studies indicate that the carbon-cyano bond cleavage proceeds through the deinsertion of silyl isocyanide from η2-iminoacyl complex B. Knowledge gained from these studies has led to the development of a new intramolecular biaryl coupling reaction in which aryl cyanides and aryl chlorides are cross-coupled.
Palladium-catalyzed insertion reactions of trimethylsilyldiazomethane
Greenman, Kevin L,Carter, David S,Van Vranken, David L
, p. 5219 - 5225 (2007/10/03)
Palladium(II) salts catalyze the Kirmse reaction of allylsulfides with trimethylsilyldiazomethane (TMSD) to give homoallylsulfides. Similarly, TMSD can intercept ArPdX intermediates generated during Stille couplings to give benzhydryl derivatives. The yie
