63326-63-6 Usage
Description
rac 1-PalMitoyl-2-chloropropanediol is a halopropanediol esterified with fatty acid, specifically palmitic acid. It is an analog of monoacylglycerols or monoalkylglycerols and has been found to possess strong inhibitory activity on the proliferation of Ehrlich ascites carcinoma (EAC) cells in suspension culture.
Uses
Used in Pharmaceutical Industry:
rac 1-PalMitoyl-2-chloropropanediol is used as an anticancer agent for its strong inhibitory activity on the proliferation of Ehrlich ascites carcinoma (EAC) cells in suspension culture. This makes it a potential candidate for the development of cancer treatments, particularly for targeting solid malignancies.
Used in Drug Development:
As an analog of monoacylglycerols or monoalkylglycerols, rac 1-PalMitoyl-2-chloropropanediol can be utilized in the development of new drugs and therapeutic agents. Its unique chemical structure and properties may offer novel approaches to addressing various medical conditions and improving patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 63326-63-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,3,2 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 63326-63:
(7*6)+(6*3)+(5*3)+(4*2)+(3*6)+(2*6)+(1*3)=116
116 % 10 = 6
So 63326-63-6 is a valid CAS Registry Number.
63326-63-6Relevant articles and documents
Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice
Zhang, Zhongfei,Yang, Puyu,Gao, Boyan,Huang, Guoren,Liu, Man,Yu, Liangli Lucy
, p. 3789 - 3795 (2019/04/10)
A novel synthetic route was designed, developed, and utilized to synthesize six high-purity 2-monochloropropanediol fatty acid esters (2-MCPD esters), a group of potential processing-induced food contaminants. A chlorine atom was introduced to C-2 of a diethyl malonate molecule, which was reduced by NaBH4 and followed by esterification using fatty acids. The reaction products were isolated and purified using silica gel columns to obtain three 2-MCPD monoesters and three diesters at about 50-54% and 56-59% yields, respectively. In addition, 2-MCPD monopalmitate and dipalmitate were examined for their acute oral toxicities in Swiss mice. The LD50 values of 2-MCPD mono- and dipalmitate were greater than 5000 mg/kg body weight (BW), along with detectable nephrotoxicity and testicular toxicity. The results of this study may promote future investigation of MCPD ester toxicology and detection.
