633294-91-4

Basic information

• Product Name: 2-Pyrrolidinone, 5-(3-butenyl)-, (5R)-
• CAS NO: 633294-91-4
• Molecular Formula: C8H13NO
• Molecular Weight: 139.197
• Mol File: 633294-91-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 5-(3-butenyl)-, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 5-(3-butenyl)-, (5R)-(633294-91-4)
• EPA Substance Registry System: 2-Pyrrolidinone, 5-(3-butenyl)-, (5R)-(633294-91-4)

Safety Data

• Hazardous Substances Data: 633294-91-4(Hazardous Substances Data)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 1034498-78-6 (2R)-(-)-2-n-butyl-5-oxopyrrolidine-1-carboxylic acid benzyl ester 
• 1212022-88-2 (5R,7aR)-5-(3-(trifluoromethyl)benzyl)hexahydropyrrolizin-3-one 
• 1212023-06-7 C₁₅H₁₉NO₂ 
• 1212022-82-6 (5R,7aR)-5-(3-methoxybenzyl)hexahydropyrrolizin-3-one 
• 1212022-99-5 (5R,7aR)-5-(3-formylbenzyl)hexahydropyrrolizin-3-one 
• 1212022-97-3 (5R,7aR)-5-(3-benzoylbenzyl)hexahydropyrrolizin-3-one 
• 1212022-91-7 (5R,7aR)-5-(4-methylbenzyl)hexahydropyrrolizin-3-one 
• 1212023-07-8 C₁₅H₁₉NO 
• 1212022-93-9 (5R,7aR)-5-(2-methylbenzyl)hexahydropyrrolizin-3-one 
• 1212022-79-1 (5R,7aR)-5-(4-phenylbenzyl)hexahydropyrrolizin-3-one 
• 1212022-95-1 (5R,7aR)-5-(3-carbomethoxybenzyl)hexahydropyrrolizin-3-one 
• 1212023-02-3 (5R,7aR)-5-(2-nitrobenzyl)hexahydropyrrolizin-3-one 
• 1109109-92-3 (5R,7aR)-5-[(phenylseleno)methyl]hexahydro-3H-pyrrolizin-3-one 
• 1109109-94-5 (5S,7aR)-5-[(phenylseleno)methyl]hexahydro-3H-pyrrolizin-3-one 

Relevant articles and documents

MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Remote stereocontrol in the Nazarov reaction: A new approach to the core of roseophilin

Three different procedures are compared to obtain properly substituted divinyl ketones in which one of the double bonds is embedded in a five-membered heterocyclic structure and therefore suitable to produce cyclopenta-fused pyrrole derivatives by the acid-catalyzed Nazarov reaction. These, on treatment with TFA, afforded 2,4-cis-disubstituted 2,3,4,5-tetrahydro-1H-cyclopenta[e] pyrrol-6-ones with high stereo-control. One of these Nazarov products was oxidized to the corresponding 4,5-dihydro-1H-cyclopenta[e]pyrrol-6-one derivative, thus obtaining an enantiopure key intermediate in the total synthesis of roseophilin.