6333-08-0

Basic information

• Product Name: 1-(naphthalen-1-yl)-3-phenylprop-2-en-1-one
• CAS NO: 6333-08-0
• Molecular Formula: C₁₉H₁₄O
• Molecular Weight: 258.3139
• Mol File: 6333-08-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 441.1°C at 760 mmHg
• Flash Point: 195.4°C
• Density: 1.153g/cm³
• Vapor Pressure: 5.57E-08mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 1-(naphthalen-1-yl)-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(naphthalen-1-yl)-3-phenylprop-2-en-1-one(6333-08-0)
• EPA Substance Registry System: 1-(naphthalen-1-yl)-3-phenylprop-2-en-1-one(6333-08-0)

Safety Data

• Hazardous Substances Data: 6333-08-0(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline solid

Odor

Strong

Structure

Contains a naphthalene ring and a phenyl group attached to a ketone functional group

Uses

a. Production of various organic compounds and pharmaceuticals
b. Organic synthesis and as a building block for more complex molecules
c. Fragrance ingredient
d. Manufacturing of dyes and pigments
e. Potential applications in the development of new drugs and medicinal compounds

Industrial and scientific importance

Diverse uses in the field of chemistry

Upstream product

• 67-56-1 methanol 
• 941-98-0 1'-naphthacetophenone 
• 124-41-4 sodium methylate 
• 100-52-7 benzaldehyde 
• 7647-01-0 hydrogenchloride 
• 10035-10-6 hydrogen bromide 
• 64-17-5 ethanol 
• 91-20-3 naphthalene 
• 61619-02-1 1-(1'-naphthyl)-allylalcohol 
• 98-80-6 phenylboronic acid 
• 100-51-6 benzyl alcohol 
• 51246-20-9 1-phenyl-1-iodoethylene 
• 66-77-3 1-naphthaldehyde 

Downstream Products

• 791787-07-0 Naphthalen-1-yl-(4-phenyl-1H-pyrrol-3-yl)-methanone 
• 50558-57-1 3-phenyl-2,3-dihydro-cyclopenta[a]naphthalen-1-one 
• 548-39-0 Perinaphthenon 
• 2515-49-3 1,5-diphenyl-3-(naphthalene-4-yl)-1H-pyrazoline 

Relevant articles and documents

Pyrazoles and pyrazolines as anti-inflammatory agents

The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via t

Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow

A general method for the aldol condensation of aromatic ketones with aldehydes was developed under continuous-flow conditions using a commercially available, strongly basic anion-exchange resin (A26) as catalyst. This procedure, in addition to exhibiting a wide substrate scope, promoted carbon-carbon bond formation under mild conditions using a quasi-stoichiometric ratio of starting reagents with good to excellent yields, thereby forming a limited amount of waste and allowing the process to be applied to sequential-flow systems. A proof of concept was developed in the first fully heterogeneously catalyzed two-step flow synthesis of donepezil, which is a blockbuster commercial anti-Alzheimer's drug.

Enantioselective Diels-Alder Reactions of Cyclohexa-1,3-diene and Chalcones Catalyzed by Intramolecular Silicon-Sulfur Lewis Pairs as Chiral Lewis Acids

The stereoselective preparation of diastereomeric dihydrosilepine-derived silicon cations decorated with another binaphthyl unit at the silicon atom is described. A sulfide donor attached to that additional binaphthyl substituent forms an intramolecular Lewis pair with the electron-deficient silicon atom, as verified by 29Si NMR spectroscopy. Both chiral sulfur-stabilized silicon cations act as catalysts in the difficult Diels-Alder reaction of cyclohexa-1,3-diene and chalcone derivatives. Both Lewis acids induce enantioselectivity, but the S,S relative configuration is superior to the S,R configuration. With the former diastereomer, enantiomeric excesses of close to 60% are obtained. These values are the highest achieved to date in this seemingly trivial cycloaddition.