633327-51-2

Basic information

• Product Name: 6-FLUORO-5-NITRO-1H-INDAZOLE
• Synonyms: 6-FLUORO-5-NITRO-1H-INDAZOLE;6-Fluoro-5-nitroindazole;5-nitro-6-fluoro-1H-indazole
• CAS NO: 633327-51-2
• Molecular Formula: C₇H₄FN₃O₂
• Molecular Weight: 181.13
• EINECS: 604-604-1
• Mol File: 633327-51-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 401.2 °C at 760 mmHg
• Flash Point: 196.4 °C
• Appearance: /
• Density: 1.629 g/cm³
• Vapor Pressure: 2.79E-06mmHg at 25°C
• Refractive Index: 1.704
• PKA: 10.92±0.40(Predicted)
• CAS DataBase Reference: 6-FLUORO-5-NITRO-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-5-NITRO-1H-INDAZOLE(633327-51-2)
• EPA Substance Registry System: 6-FLUORO-5-NITRO-1H-INDAZOLE(633327-51-2)

Safety Data

• Hazardous Substances Data: 633327-51-2(Hazardous Substances Data)

Usage

General Description

6-Fluoro-5-nitro-1H-indazole is a chemical compound with the molecular formula C7H4FN3O2. It is a derivative of indazole and contains a fluorine atom and a nitro group. 6-fluoro-5-nitro-1H-indazole is used in the pharmaceutical industry as a building block for the synthesis of various compounds and as a potential pharmacophore for drug discovery. It has been studied for its potential pharmacological activities, such as antimicrobial, antifungal, and anti-inflammatory properties. The presence of the fluorine and nitro groups in the molecule makes it a valuable target for medicinal chemistry research and drug development.

InChI:InChI=1/C7H4FN3O2/c8-5-2-6-4(3-9-10-6)1-7(5)11(12)13/h1-3H,(H,9,10)

Upstream product

• 348-25-4 6-fluoro-1H-indazole 
• 367-29-3 3-fluoro-6-methylaniline 
• 709046-13-9 6-fluoro-1-acetylindazole 
• 633327-50-1 5-fluoro-2-methyl-4-nitrophenylamine 
• 446-10-6 2-nitro-4-fluorotoluene 
• 366-49-4 5’-fluoro-2’-methylacetanilide 
• 633327-49-8 N-(5-fluoro-2-methyl-4-nitrophenyl)acetamide 

Downstream Products

• 709046-14-0 5-amino-6-fluoro-1H-indazole 

Relevant articles and documents

Cell necrosis inhibitor, and preparation method and application thereof

The invention provides a cell necrosis inhibitor, and a preparation method and application thereof. Particularly, the invention provides an inhibitor for inhibiting cell necrosis and/or human receptorinteracting protein 1 kinase (RIP1). The inhibitor has

Indazole Compounds as IRAK4 Inhibitors

The present invention provides indazole compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors, wherein Z1, Z2, R1, R2, R3, ‘m’ and ‘n’ have the meanings given in the specification, and pharmaceutically acceptable salts or stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical compositions comprising at least one of the compounds of the compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient.

PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X-Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).