63335-25-1 Usage
Description
Malabaricone C is a diarylnonanoid compound found in Myristica, exhibiting a range of biological activities, including antioxidant, antimicrobial, and cytotoxic properties. It demonstrates strong radical scavenging capabilities, as well as the ability to inhibit sphingomyelin synthase activity and reduce obesity-related parameters in animal models.
Uses
Used in Pharmaceutical Industry:
Malabaricone C is used as an antimicrobial agent for its in vitro activity against S. aureus, B. subtilis, and C. albicans, with MICs ranging from 2-32 μg/ml. This makes it a potential candidate for the development of new antibiotics to combat resistant bacterial strains.
Used in Antioxidant Applications:
Malabaricone C is used as a natural antioxidant, capable of scavenging 59.9% of DPPH radicals at a concentration of 7 μg/ml. Its antioxidant properties can be utilized in various health and skincare products to protect against oxidative stress and promote overall well-being.
Used in Cancer Research:
Malabaricone C is used as a cytotoxic agent against various cancer cell lines, including A549, HL-60, and MCF-7, with IC50s of 12.3, 46.1, and 10.8 μM, respectively. Its cytotoxic effects make it a promising candidate for further research into cancer treatment and therapy.
Used in Obesity Management:
Malabaricone C is used as a weight management compound, as it has been shown to decrease body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet. This suggests its potential use in the development of treatments for obesity and related metabolic disorders.
Used in Enzyme Inhibition Research:
Malabaricone C is used as an inhibitor of sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates, with IC50s of 3 and 1.5 μM, respectively. Its ability to inhibit these enzymes may have implications in the study and treatment of lipid metabolism and related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 63335-25-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,3,3 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 63335-25:
(7*6)+(6*3)+(5*3)+(4*3)+(3*5)+(2*2)+(1*5)=111
111 % 10 = 1
So 63335-25-1 is a valid CAS Registry Number.
63335-25-1Relevant articles and documents
Total Syntheses of Malabaricones B and C via a Cross-Metathesis Strategy
Kundu, Kshama,Nayak, Sandip K.
, p. 1776 - 1782 (2017/06/28)
The malabaricones A-D belong to the class of diarylnonanoids isolated from the Myristicaceae family of plants. Although malabaricone C displayed various interesting biological activities, its isolation remains tedious due to its close chemical similarity to malabaricones A, B, and D. Therefore, development of an efficient synthesis route has become essential to cater to the need of large amounts of malabaricone C for its pharmacological profiling. So far there is only one report of the synthesis of malabaricone C through a lengthy sequence of reactions. We have developed an efficient and short route for the syntheses of malabaricones B and C, which will also provide a convenient access to all other members of the malabaricone family. Synthesis of an important building block, -aryl heptyl bromide, employed in the synthesis was realized by adopting a cross-metathesis reaction as the key step.
Synthesis of malabaricones, diarylnonanoids occurring in myristicaceous plants
Tsuda,Hosoi,Goto
, p. 18 - 22 (2007/10/02)
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