6336-03-4

Basic information

• Product Name: benzyl naphthalen-1-ylcarbamate
• CAS NO: 6336-03-4
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.3172
• Mol File: 6336-03-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 419.3°C at 760 mmHg
• Flash Point: 207.4°C
• Density: 1.239g/cm³
• Vapor Pressure: 3.07E-07mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: benzyl naphthalen-1-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl naphthalen-1-ylcarbamate(6336-03-4)
• EPA Substance Registry System: benzyl naphthalen-1-ylcarbamate(6336-03-4)

Safety Data

• Hazardous Substances Data: 6336-03-4(Hazardous Substances Data)

Upstream product

• 134-32-7 1-amino-naphthalene 
• 501-53-1 benzyl chloroformate 
• 104-57-4 benzyl formate 
• 72594-62-8 naphthalen-1-yl-carbamic acid tert-butyl ester 

Downstream Products

• 352208-32-3 4-[3-(3-tert-butyl-5-methoxy-2-methoxymethoxy-phenyl)-1-naphthalen-1-yl-ureido]-butyric acid ethyl ester 
• 1292296-71-9 methylthiocarbamic acid (S)-1-naphthalen-1-yl-1-phenylethyl ester 
• 1292296-81-1 (S)-1-naphthalen-1-yl-1-phenylethanethiol 
• 1292296-59-3 methylnaphthalen-1-ylthiocarbamic acid (S)-1-phenylethyl ester 
• 2216-68-4 N-methylnaphthalen-1-amine 
• 134-32-7 1-amino-naphthalene 

Relevant articles and documents

Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine

Facile reduction of aryl halides with a combination of 5% Pd/C, B2(OH)4, and 4-methylmorpholine is reported. Aryl bromides, iodides, and chlorides were efficiently reduced. Aryl dihalides containing two different halogen atoms underwent selective reduction: I over Br and Cl, and Br over Cl. Beyond these, aryl triflates were efficiently reduced. This combination was broadly general, effectuating reductions of benzylic halides and ethers, alkenes, alkynes, aldehydes, and azides, as well as for N-Cbz deprotection. A cyano group was unaffected, but a nitro group and a ketone underwent reduction to a low extent. When B2(OD)4 was used for aryl halide reduction, a significant amount of deuteriation occurred. However, H atom incorporation competed and increased in slower reactions. 4-Methylmorpholine was identified as a possible source of H atoms in this, but a combination of only 4-methylmorpholine and Pd/C did not result in reduction. Hydrogen gas has been observed to form with this reagent combination. Experiments aimed at understanding the chemistry led to the proposal of a plausible mechanism and to the identification of N,N-bis(methyl-d3)pyridin-4-amine (DMAP-d6) and B2(OD)4 as an effective combination for full aromatic deuteriation. (Figure presented.).

Silver-Catalyzed para -Selective C-H Amination of 1-Naphthylamides with Azodicarboxylates at Room Temperature

A simple and efficient protocol for para -selective C-H amination of 1-naphthylamide derivatives under silver catalysis is described. This reaction system could proceed without the help of directing group and a broad range of substrates were proved to be well tolerated. In addition, control experiments suggested that this reaction might not proceed via a single-electron-transfer process.

Microwave-assisted carbamoylation of amines

The influence of microwave irradiation on the reaction of various amines with benzyl chloroformate and di-tert-butyl dicarbonate was investigated. Microwave irradiation was successfully applied to the carbamoylation of several nonfunctionalized and functionalized amines, including amino acids and nucleobases, leading to satisfactory to high product conversion within very short reaction times. Copyright Taylor & Francis Group, LLC.