6338-36-9

Basic information

• Product Name: 1,4:3,6-dianhydro-2,5-di-O-benzylhexitol
• CAS NO: 6338-36-9
• Molecular Formula: C₂₀H₂₂O₄
• Molecular Weight: 326.3863
• Mol File: 6338-36-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 456.9°C at 760 mmHg
• Flash Point: 143.1°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.22E-08mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1,4:3,6-dianhydro-2,5-di-O-benzylhexitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4:3,6-dianhydro-2,5-di-O-benzylhexitol(6338-36-9)
• EPA Substance Registry System: 1,4:3,6-dianhydro-2,5-di-O-benzylhexitol(6338-36-9)

Safety Data

• Hazardous Substances Data: 6338-36-9(Hazardous Substances Data)

Usage

Appearance

White crystalline

Natural occurrence

Not naturally occurring

Parent compound

Isosorbide (a six-membered sugar alcohol)

Derivative

Di-benzylated derivative

Usage

Intermediate in the synthesis of various pharmaceuticals

Applications

Cardiovascular and diuretic pharmaceuticals

Additional uses

Starting material in the manufacture of specialty polymers and resins

Structure

Unique structure useful in the development of new materials and pharmaceuticals with specific properties and applications.

Upstream product

• 100-44-7 benzyl chloride 
• 641-74-7 1,4:3,6-dianhydro-D-mannitol 
• 652-67-5 Isosorbide 
• 100-39-0 benzyl bromide 

Downstream Products

• 1228508-01-7 3-[(2S,5R)-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]oct-2-yloxy]-6-benzyloxy-(3R,3aS,6R,6aR)-hexahydrofuro[3,2-b]-furan 
• 1228508-02-8 3-[(2R,5S)-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]oct-2-yloxy]-6-benzyloxy-(3R,3aS,6R,6aR)-hexahydrofuro[3,2-b]-furan 

Relevant articles and documents

Synthesis of novel chiral imidazolium-based ionic liquids derived from isosorbide and their applications in asymmetric aza Diels-Alder reaction

A novel family of chiral imidazolium-based ionic liquids containing a chiral moiety and a free hydroxyl function has been designed and synthesized using isosorbide as a biorenewable substrate. These chiral ionic liquids were found to catalyze the aza Diels-Alder reaction to give good yields and moderate diastereoselectivities. Chiral ionic liquids are recycled while their efficiency is preserved.

Ethers of bisanhydrohexitols

A novel method for the synthesis of ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, is disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. Anhydrosugar ethers are