63381-38-4

Basic information

• Product Name: N-(3-HYDROXYPHENYL)MALEIMIDE
• Synonyms: N-(3-HYDROXYPHENYL)MALEIMIDE;1-(3-Hydroxyphenyl)-1H-pyrrole-2,5-dione;m-Maleimidophenol;N-(m-Hydroxyphenyl)maleimide
• CAS NO: 63381-38-4
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Mol File: 63381-38-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(3-HYDROXYPHENYL)MALEIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-HYDROXYPHENYL)MALEIMIDE(63381-38-4)
• EPA Substance Registry System: N-(3-HYDROXYPHENYL)MALEIMIDE(63381-38-4)

Safety Data

• Hazardous Substances Data: 63381-38-4(Hazardous Substances Data)

Upstream product

• 28122-54-5 N-(m-hydroxyphenyl)-maleamic acid 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 108-31-6 maleic anhydride 
• 591-27-5 m-Hydroxyaniline 

Downstream Products

• 13676-54-5 1,1'-(methylenedi-4,1-phenylene)bismaleimide 
• 1258548-45-6 2-(1-(3-hydroxyphenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal 
• 1364041-35-9 C₂₀H₁₆N₂O₅ 

Relevant articles and documents

Iterative Arylation of Itaconimides with Diazonium Salts through Electrophilic Palladium Catalysis: Divergent β-H-Elimination Pathways in Repetitive Matsuda-Heck Reactions

N-Arylitaconimides, accessible from maleic anhydride, anilines, and paraformaldehyde, react with arene diazonium salts in Pd-catalyzed Matsuda-Heck arylation to the pharmacologically relevant E-configured 3-arylmethylidene pyrrolidine-2,5-diones (also kno

DABCO-catalyzed [3+2] cycloaddition reactions of azomethine imines with N-aryl maleimides: Facile access to dinitrogen-fused heterocycles

DABCO-catalyzed [3+2] cycloaddition of azomethine imines with maleimides has been developed. This method could efficiently furnish dinitrogen-fused tetracyclic heterocycles in high levels of regioselectivity and with good yields.

Synthesis of New Bifunctional Maleimide Compounds for the Preparation of Chemoimmunoconjugates

Bifunctional maleimide compounds are suitable for binding small molecules to carrier proteins in that they bind to the sulfhydryl group of proteins through the double bond of the maleimide group and to molecules of low molecular weight (e.g. anticancer drugs) through a functional group X. 18 maleimide compounds of the general formula Maleimid-R-X (R = phenylene, benzyl-, methylene-, ethylene, or a m-benzoylethylamide group and X = hydroxy-, amino-, hydrazino-, carboxylic acid-, carboxylic anhydride-, carboxylic acid chloride-, carboxylic acid hydrazide-, oxycarbonylchloride-, aldehyde, keto-, or p-toluenesulfonate-group) were synthesized and characterized through 1H- and 13C-NMR-spectroscopy, elemental analysis, and mass spectrometry.