6339-26-0

Basic information

• Product Name: 4-[(4-methylphenyl)sulphonyl]morpholine
• Synonyms: 4-[(4-methylphenyl)sulphonyl]morpholine;(4-Methylphenyl)morpholino sulfone;4-(p-Tolylsulfonyl)morpholine;Morpholine,4-[(4-methylphenyl)sulfonyl]-
• CAS NO: 6339-26-0
• Molecular Formula: C₁₁H₁₅NO₃S
• Molecular Weight: 241.3067
• EINECS: 228-731-2
• Mol File: 6339-26-0.mol
• Article Data: 85

Chemical Properties

• Boiling Point: 385.3°C at 760 mmHg
• Flash Point: 186.8°C
• Appearance: /
• Density: 1.256g/cm³
• Vapor Pressure: 3.85E-06mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 4-[(4-methylphenyl)sulphonyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-methylphenyl)sulphonyl]morpholine(6339-26-0)
• EPA Substance Registry System: 4-[(4-methylphenyl)sulphonyl]morpholine(6339-26-0)

Safety Data

• Hazardous Substances Data: 6339-26-0(Hazardous Substances Data)

Usage

General Description

4-[(4-methylphenyl)sulphonyl]morpholine, also known as rilapladib, is a chemical compound with the molecular formula C13H17NO3S. It is a sulphonamide derivative and a selective inhibitor of the secretory phospholipase A2 enzyme. This enzyme is involved in the inflammatory response, making rilapladib a potential medication for the treatment of inflammatory conditions such as atherosclerosis, cardiovascular disease, arthritis, and asthma. It functions by blocking the production of inflammatory chemicals in the body. Research on rilapladib has shown promise in the treatment of various inflammatory diseases, making it a subject of scientific interest and potential therapeutic use.

InChI:InChI=1/C11H15NO3S/c1-10-2-4-11(5-3-10)16(13,14)12-6-8-15-9-7-12/h2-5H,6-9H2,1H3

Upstream product

• 34270-90-1 2,2'-diiodoethyl ether 
• 70-55-3 toluene-4-sulfonamide 
• 110-91-8 morpholine 
• 536-57-2 p-toluene sulfinic acid 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 29981-92-8 1-tosyl-3-methyl-imidazolium chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 92163-82-1 3-(p-tolylsulfonyl)-2(3H)-benzothiazolone 
• 23328-69-0 4-chloromorpholine 
• 18522-92-4 sodium p-toluenesulfonamide 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 75825-44-4 N,N'-ditosylpropylenediamine-1,2 disodium salt 
• 7460-82-4 diethylene glycol ditosylate 

Downstream Products

• 22457-02-9 4-(4-nitromethyl-benzenesulfonyl)-morpholine 
• 138385-04-3 4-((4-(bromomethyl)benzene)sulfonyl)morpholine 
• 110-91-8 morpholine 
• 106-45-6 para-thiocresol 
• 138385-02-1 N⁶-<4-(morpholinosulfonyl)benzyl>-6-aminobenzindol-2(1H)-one 
• 138385-03-2 N⁶-<4-(morpholinosulfonyl)benzyl>-6-amino-5-methylbenzindol-2(1H)-one 
• 138384-66-4 N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-aminobenzindol-2(1H)-one 
• 138384-68-6 (2-Imino-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-[4-(morpholine-4-sulfonyl)-benzyl]-amine 
• 138385-01-0 N⁶-<4-(morpholinosulfonyl)benzyl>-6-amino-5-chlorobenzindol-2(1H)-one 
• 138384-76-6 N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-methylbenzindol-2(1H)-one 
• 138384-58-4 N⁶-<4-(morpholinosulfonyl)benzyl>-N⁶-methyl-6-amino-5-chlorobenzindol-2(1H)-one 
• 138384-59-5 (5-Chloro-2-imino-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-[4-(morpholine-4-sulfonyl)-benzyl]-amine 
• 138384-60-8 (2-Imino-5-methylsulfanyl-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-[4-(morpholine-4-sulfonyl)-benzyl]-amine 
• 138384-79-9 (2-Imino-5-methyl-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-[4-(morpholine-4-sulfonyl)-benzyl]-amine 

Relevant articles and documents

Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light

Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.

Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.

Novel method for preparing oxygen heterocyclic compound through ionic liquid catalysis

The invention discloses a novel method for preparing an oxygen heterocyclic compound through ionic liquid catalysis. The ionic liquid catalytic system has the advantages of high efficiency, simplicity, mild reaction conditions, no metal participation, no by-product, simple separation and the like and can efficiently catalyze fatty diether metathesis cyclization to prepare an oxygen heterocyclic compound and has very high industrial application value.