6339-60-2

Basic information

• Product Name: [(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]acetic acid
• Synonyms: [(1-Methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]acetic acid; Acetic acid, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-
• CAS NO: 6339-60-2
• Molecular Formula: C₆H₇N₃O₄S
• Molecular Weight: 217.2025
• Mol File: 6339-60-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 508.7°C at 760 mmHg
• Flash Point: 261.4°C
• Density: 1.67g/cm³
• Vapor Pressure: 3.6E-11mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: [(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]acetic acid(6339-60-2)
• EPA Substance Registry System: [(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]acetic acid(6339-60-2)

Safety Data

• Hazardous Substances Data: 6339-60-2(Hazardous Substances Data)

Usage

Description

[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]acetic acid, also known as MNIA, is a derivative of imidazole with a nitro group and a methyl group. It is a sulfhydryl-containing compound that has potential therapeutic applications due to its ability to act as a nitroreductase substrate.

Uses

Used in Cancer Therapy:
MNIA is used as an anticancer agent for its potential to be activated by nitroreductase enzymes in cancer cells, leading to the release of toxic byproducts that can induce cell death. This selective activation in cancer cells makes MNIA a promising candidate for targeted cancer therapy.
Used in Radioprotection:
MNIA is used as a radioprotective agent due to its ability to scavenge free radicals and protect cells from radiation-induced damage. This property can be beneficial in various medical and industrial applications where exposure to radiation is a concern, such as cancer radiotherapy and radiation workers' protection.
Used in Pharmaceutical Research:
MNIA's unique chemical structure and biological properties make it a promising candidate for further research in the fields of cancer therapy and radioprotection. Its potential applications in drug development and understanding the mechanisms of cancer cell death and radiation protection can lead to the discovery of new therapeutic strategies and agents.

Upstream product

• 4897-25-0 5-chloro-1-methyl-4-nitroimidazole 
• 68-11-1 mercaptoacetic acid 

Relevant articles and documents

Synthesis of 1-methyl-4-nitro-5-substituted-imidazole and substituted imidazolothiazole derivates as possible antiparasitic agents

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