6341-33-9Relevant articles and documents
C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock
Oshima, Tsuyoshi,Yamanaka, Iori,Kumar, Anupriya,Yamaguchi, Junichiro,Nishiwaki-Ohkawa, Taeko,Muto, Kei,Kawamura, Rika,Hirota, Tsuyoshi,Yagita, Kazuhiro,Irle, Stephan,Kay, Steve A.,Yoshimura, Takashi,Itami, Kenichiro
, p. 7193 - 7197 (2015)
The synthesis and functional analysis of KL001 derivatives, which are modulators of the mammalian circadian clock, are described. By using cutting-edge C￡H activation chemistry, a focused library of KL001 derivatives was rapidly constructed, which enabled
Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock
Lee, Jae Wook,Hirota, Tsuyoshi,Kumar, Anupriya,Kim, Nam-Jung,Irle, Stephan,Kay, Steve A.
supporting information, p. 1489 - 1497 (2015/09/07)
Small-molecule probes have been playing prominent roles in furthering our understanding of the molecular underpinnings of the circadian clock. We previously discovered a carbazole derivative, KL001 (N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylme
Carbazole-Containing Sulfonamides as Cryptochrome Modulators
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Paragraph 0264-0265, (2013/11/19)
The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.
