6342-63-8

Basic information

• Product Name: 1-(2-bromo-5-methoxy-phenyl)ethanone
• Synonyms: 1-(2-bromo-5-methoxy-phenyl)ethanone;3-Acetyl-4-bromoanisole;1-(2-Bromo-5-methoxyphenyl)ethan-1-one, 3-Acetyl-4-bromoanisole
• CAS NO: 6342-63-8
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Mol File: 6342-63-8.mol
• Article Data: 29

Chemical Properties

• Melting Point: 102°C
• Boiling Point: 288.9°C at 760 mmHg
• Flash Point: 128.5°C
• Appearance: /
• Density: 1.421g/cm³
• Vapor Pressure: 0.00228mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-bromo-5-methoxy-phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-5-methoxy-phenyl)ethanone(6342-63-8)
• EPA Substance Registry System: 1-(2-bromo-5-methoxy-phenyl)ethanone(6342-63-8)

Safety Data

• Hazardous Substances Data: 6342-63-8(Hazardous Substances Data)

Usage

Preparation

Obtained by action of pyridinium chlorochromate with 1-(2-bromo-5-methoxy) ethanol.

InChI:InChI=1/C9H9BrO2/c1-6(11)8-5-7(12-2)3-4-9(8)10/h3-5H,1-2H3

Upstream product

• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 
• 105-53-3 diethyl malonate 
• 71095-23-3 1-(2′-bromo-5′-methoxyphenyl)ethan-1-ol 
• 18457-04-0 bis(trimethylsilyl) malonate 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 591-31-1 3-methoxy-benzaldehyde 
• 586-38-9 3-Methoxybenzoic acid 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 544-97-8 dimethyl zinc(II) 
• 75-16-1 methylmagnesium bromide 
• 374803-67-5 2-bromo-N,5-dimethoxy-N-methylbenzamide 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 108059-70-7 2-(2-Acetyl-4-methoxyphenylthio)benzoesaeure 
• 71095-17-5 1-Amino-2-(2-brom-5-methoxyphenyl)-propan-2-ol 
• 108081-63-6 2-(2-Acetyl-4-methoxyphenylthio)benzoesaeure-methylester 
• 841299-58-9 1-(2-cyclohexyl-5-methoxy-phenyl)-ethanone 
• 841298-81-5 1-(4'-chloro-4-methoxy-biphenyl-2-yl)-ethanone 
• 28238-27-9 2-bromo-1-(2-bromo-5-methoxyphenyl)ethanone 
• 1284294-03-6 C₁₆H₁₃NO₂ 
• 1284294-00-3 C₁₈H₁₃NO₂ 
• 57183-50-3 6-methoxy-2-phenyl-1H-quinolin-4-one 
• 18617-96-4 2-Phenyl-4-merapto-6-methoxychinolin 
• 1233355-53-7 LDN-209964 
• 1350844-20-0 1-(5-methoxy-2-(pent-1-ynyl)phenyl)ethanone 
• 1354364-30-9 2-(2-bromo-5-methoxyphenyl)butan-2-ol 
• 1361385-63-8 1-bromo-4-methoxy-2-(2-methoxy-1-methylethenyl)benzene 

Relevant articles and documents

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

Divergent Access to Benzocycles through Copper-Catalyzed Borylative Cyclizations

A copper-catalyzed chemodivergent approach to five- and six-membered benzocycles from dienyl arenes tethered with a ketone has been developed. Through proper choice of coordinating ligands and catalytic conditions, copper-catalyzed borylative cyclization of a single dienyl arene can be diverted to two different pathways, leading to indanols and dihydronaphthalenols with high stereoselectivity. The chiral bidentate bisphosphine ligand (S,S)-Ph-BPE was optimal for asymmetric copper-allyl addition to a tethered ketone via a boat-like transition state, whereas NHC ligands led to boro-allyl addition producing indanols with high diastereoselectivity. (Figure presented.).

Enantiotropic Transformation of Carbethoxyhydrazones of Acetophenones

Abstract: Hydrazinecarboxylates have been synthesized by reacting substituted acetophenones with carbethoxyhydrazine. One of product is formed as a mixture of E- and Z-isomers. In the process of measuring the melting point of the resulting hydrazinecarbox