63423-94-9

Basic information

• Product Name: 1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine
• Synonyms: 1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine;4,6-Dichloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-iMidazo[4,5-c]pyridine;QUGRSJQZWTYDHN-UHFFFAOYSA-N
• CAS NO: 63423-94-9
• Molecular Formula: C17H19ClN4O7
• Molecular Weight: 446.23878
• Product Categories: Bases & Related Reagents;Nucleotides;Carbohydrates & Derivatives;Intermediates
• Mol File: 63423-94-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 239-242°C
• Appearance: /
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine(63423-94-9)
• EPA Substance Registry System: 1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine(63423-94-9)

Safety Data

• Hazardous Substances Data: 63423-94-9(Hazardous Substances Data)

Usage

Description

1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine is a chemical compound that serves as an intermediate in the synthesis of 3-Deazaadenosine (D200875), a nucleoside analog with potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine is used as a key intermediate in the synthesis of 3-Deazaadenosine (D200875), a nucleoside analog with potential therapeutic applications. It plays a crucial role in the development of new drugs for the treatment of various diseases, including cancer and viral infections.

Upstream product

• 2589-12-0 4,6-dichloro-1H-imidazo<4,5-c>pyridine 
• 13035-61-5 1,2,3,5-tetraacetylribose 
• 2897-43-0 2,6-dichloro-3-nitropyridin-4-amine 
• 101079-63-4 3,4-diamino-2,6-dichloropyridine 
• 39727-26-9 β-D-Ribofuranose-1,2,3,5-tetraacetate 

Downstream Products

• 40656-71-1 2,6-dichloro-9-(β-D-ribofuranosyl)-3-deazapurine 

Relevant articles and documents

MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF

Compounds that modulate the conversion of AMP to adenosine by 5'- nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5'-nucleotidase, ecto is also provided.

Deaza- and deoxyadenosine derivatives: Synthesis and inhibition of animal viruses as human infection models

N6-Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.