63429-97-0

Basic information

• Product Name: N-(4-TERT-BUTYL-PHENYL)-FORMAMIDE
• Synonyms: N-(4-TERT-BUTYL-PHENYL)-FORMAMIDE
• CAS NO: 63429-97-0
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 63429-97-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 310.0±21.0 °C(Predicted)
• Appearance: /
• Density: 1.025±0.06 g/cm3(Predicted)
• PKA: 15.00±0.70(Predicted)
• CAS DataBase Reference: N-(4-TERT-BUTYL-PHENYL)-FORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-TERT-BUTYL-PHENYL)-FORMAMIDE(63429-97-0)
• EPA Substance Registry System: N-(4-TERT-BUTYL-PHENYL)-FORMAMIDE(63429-97-0)

Safety Data

• Hazardous Substances Data: 63429-97-0(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 769-92-6 4-tert-Butylaniline 
• 142-04-1 aniline hydrochloride 
• 3282-56-2 4-tert-butylnitrobenzene 
• 124-38-9 carbon dioxide 
• 2258-42-6 formyl acetic anhydride 
• 96-26-4 dihydroxyacetone 
• 667-27-6 Ethyl bromodifluoroacetate 
• 68-12-2 N,N-dimethyl-formamide 
• 51673-84-8 dimethoxyacetaldehyde 
• 3397-76-0 N,N-Dimethylformamide Hydrochloride 
• 2909-79-7 4-tert-butyl-N,N-dimethylaniline 

Downstream Products

• 5279-59-4 4-(1,1-dimethylethyl)-N-methylbenzenamine 
• 4210-32-6 4-tert-butyl benzonitrile 
• 5279-57-2 N-(4-isopropylphenyl)-N-methylformamide 
• 5279-60-7 N-(4-(tert-butyl)phenyl)-N-methylformamide 
• 1582273-36-6 isopropyl (4-(tert-butyl)phenyl)carbamate 
• 1582273-30-0 butyl (4-(tert-butyl)phenyl)carbamate 
• 1943-67-5 4-(t-butyl)phenyl isocyanate 
• 459-25-6 N-(4-fluorophenyl)formamide 
• 602262-03-3 1-(tert-butyl)-4-isocyanobenzene 

Relevant articles and documents

Copper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants

A novel tandem N-dealkylation and N-methyl aerobic oxidation of tertiary aromatic amines to N-arylformamides using copper and TEMPO has been developed. This methodology suggested an alternative synthetic route from N-methylarylamines to N-arylformamides.

DMF·HCl as a versatile and straightforward N- and O-formylating agent

Inspired by the serendipitous isolation of N-formylpiperazines when we attempted the synthesis of a series of piperazines, we have developed a straightforward methodology for the N- and O- formylation of secondary cyclic amines, anilines and steroids, respectively. Such approach is based on the hitherto non-reported use of DMF·HCl complex, as a versatile and easily-available formylating system that can be stored without apparent loss of activity.

A Practical Approach for the Transamidation of N, N-Dimethyl Amides with Primary Amines Promoted by Sodium tert-Butoxide under Solvent-Free Conditions

A practical sodium tert-butoxide (NaO t Bu)-mediated protocol is disclosed for the transamidation of various N, N-dimethyl amides with primary amines to afford the corresponding amides in moderate to good yields at room temperature under solvent-free conditions. This protocol features a facile work-up procedure and good functional group compatibility, especially for N, N-dimethyl amides with long-chain alkyl groups and heteroatom-containing amines. Notably, a few representative gram-scale reactions proceed smoothly to furnish the desired amides in high yields, which demonstrates the potential of this process for further practical applications. Several control experiments are carried out and a plausible mechanism is provided.