63439-30-5Relevant articles and documents
Synthetic phosphatidyl cholines useful in forming liposomes
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, (2008/06/13)
Lower-ω-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the ω-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.
Polymerized Phosphatidylcholine Vesicles. Synthesis and Characterization
Regen, Steven L.,Singh, Alok,Oehme, Guenter,Singh, Maninder
, p. 791 - 795 (2007/10/02)
The synthesis and characterization of photopolymerized vesicles derived from bis-L-α-phosphatidylcholine (3) 1--2-palmitoyl-L-α-phosphatidylcholine (4), and 1-palmitoyl-2--L-α-phosphatidylcholine (5) are described.Ultrasonic irradiation of 3, 4, 5, 20percent 3 + 80percent 4, and 20percent 3 + 80percent 5 in water at 50 deg C yields opalescent to optically clear dispersions.Electron microscopy, entrapment of sucrose, and permeability measurements provide strong evidence for closed multilamellar vesicles having diameters ranging between 350 and 1400 Angstroem.Fourier transform 1H NMR spectra of the aqueous dispersions as well as IR spectra of chloroform extracts establish that no significant lipid decomposition occurs during vesicle preparation.Direct UV irradiation (254 nm) produces polymerized analogues of similar size and shape which (1) entrap sucrose, (2) show reduced permeability, and (3) exhibit enchanced stability.